Structure activity relationships of selected naphthalene derivatives

Journal Article · Sat Jan 01 00:00:00 EST 1983 · Ecotoxicol. Environ. Saf.; (United States)

DOI:https://doi.org/10.1016/0147-6513(83)90065-9· OSTI ID:5997318

Schultz, T W; Dumont, J N; Sankey, F D; Schmoyer, Jr, R L

Twenty-two derivatives of naphthalene were assayed under an acute static regime with biological activity being monitored as population growth of Tetrahymena pyriformis. Activity varied over one log unit. Substituent constant structure-activity analyses revealed the model, log BR = 0.282Ha + 0.352..pi.. + 0.692F + 0.334/sup 1/X/sub sub//sup v/ - 0.326R + 0.027, to be best and to account for 85% of the variation in log BR (BR, biological response; Ha, hydrogen acceptance; ..pi.., hydrophobic substituent constant; F, polar electronic substituent constant, /sup 1/X/sub sub//sup v/, substituent molar connectivity index; R, resonance electronic substituent constant). The Ha and ..pi.. parameters are the most important, accounting for 71% of the log BR variability. 21 references, 1 figure, 7 tables.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5997318
• Journal Information: Ecotoxicol. Environ. Saf.; (United States), Vol. 7
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NAPHTHALENE
MUTAGEN SCREENING
STRUCTURE-ACTIVITY RELATIONSHIPS
TETRAHYMENA
GROWTH
EXPERIMENTAL DATA
MATHEMATICAL MODELS
ANIMALS
AROMATICS
CILIATA
CONDENSED AROMATICS
DATA
HYDROCARBONS
INFORMATION
INVERTEBRATES
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
PROTOZOA
SCREENING
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)