Comparative study regarding the association of alpha-2u globulin with the nephrotoxic mechanism of certain petroleum-based air force fuels. Annual report 1 Jul 90-30 Jun 91

Technical Report · Wed Aug 14 00:00:00 EDT 1991

OSTI ID:5996407

Eurell, T E

Adult male rats have a dose and time dependent renal proximal tubular degeneration induced by certain hydrocarbon compounds. This degeneration is associated with a low molecular weight urinary protein called alpha 2U globulin. We are using rat strain variation (Fisher 344 and NCI Black Reiter) and different hydrocarbon compounds (JP-4, JP-8, decalin and trimethylpentane) to investigate the hydrocarbon-induced nephrotoxic response. Preliminary histochemical and morphometric evaluation of NCI-Black Reiter rats exposed to JP-8 suggests that this strain undergoes an intermediate form of the hydrocarbon-induced nephrotoxicity when compared to the albino Fisher 344 strain.

• Research Organization: Illinois Univ., Urbana, IL (United States). Dept. of Veterinary Biosciences
• OSTI ID: 5996407
• Report Number(s): AD-A-240363/2/XAB; CNN: AFOSR-90-0303
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HYDROCARBONS
TOXICITY
TUBULES
SENSITIVITY
FUELS
GLOBULINS
METABOLISM
PATHOLOGICAL CHANGES
PETROLEUM PRODUCTS
RATS
VARIATIONS
ANIMALS
BODY
KIDNEYS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology