A new kinetic model for human iodine metabolism

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5995695

Ficken, V J; Allen, E W; Adams, G D

A new kinetic model of iodine metabolism incorporating preferential organification of tyrosil (TYR) residues of thyroglobulin is developed and evaluated for euthyroid (n=5) and hyperthyroid (n=11) subjects. Iodine and peripheral T4 metabolims were measured with oral /sup 131/I-NaI and intravenous /sup 125/I-74 respectively. Data (obtained over 10 days) and kinetic model are analyzed using the SAAM27 program developed by Berman (1978). Compartment rate constants (mean rate per hour +- ISD) are tabulated in this paper. Thyroid and renal iodide clearance compare favorably with values reported in the literature. TYR rate constants were not unique; however, values obtained are within the range of rate constants determined from the invitro data reported by others. Intraluminal iodine as coupled TYR is predicted to be 21% for euthyroid and 59% for hyperthyroid subjects compared to analytical chemical methods of 30% and 51% respectively determined elsewhere. The authors plan to evaluate this model as a method of predicting the thyroid radiation dose from orally administered I/sup 131/.

• Research Organization: Univ. of Oklahoma Health Sciences Center, Oklahoma City, OK
• OSTI ID: 5995695
• Report Number(s): CONF-850611-; TRN: 87-039132
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
IODINE
METABOLISM
IODINE 125
DIAGNOSTIC USES
TISSUE DISTRIBUTION
IODINE 131
THYROGLOBULIN
THYROID
RADIATION DOSES
BIOLOGICAL PATHWAYS
HYPOTHYROIDISM
KIDNEYS
MATHEMATICAL MODELS
ORAL ADMINISTRATION
ORGANIC IODINE COMPOUNDS
RADIOTHERAPY
RETENTION FUNCTIONS
TYROSINE
UPTAKE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENDOCRINE DISEASES
ENDOCRINE GLANDS
FUNCTIONS
GLANDS
GLOBULINS
HALOGENS
HYDROXY ACIDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NONMETALS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RADIOLOGY
THERAPY
USES
550501* - Metabolism- Tracer Techniques
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)