Effect of manganese treatment on the levels of neurotransmitters, hormones, and neuropeptides: modulation by stress

Journal Article · Wed Aug 01 00:00:00 EDT 1984 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(84)90092-6· OSTI ID:5995243

Hong, J S; Jung, C R; Seth, P K; Mason, G; Bondy, S C

Six weeks of daily intraperitoneal injection with manganese chloride (15 mg/kg body wt) reduced the normal weight gain of male Fischer-344 rats. This treatment depressed plasma testosterone and corticosterone levels, but prolactin levels were unaffected. The only significant changes in the levels of a variety of neuropeptides assayed in several regions were increases in the levels of hypothalamic substance P and pituitary neurotensin. Striatal serotonin, dopamine, and their metabolites were unchanged in manganese-exposed rats relative to saline-injected controls. However, the stress of injection combined with the effect of manganese appeared to significantly increase concentrations of striatal monoamines relative to uninjected controls.

• Research Organization: National Inst. of Environmental Health Sciences, Research Triangle Park, NC
• OSTI ID: 5995243
• Journal Information: Environ. Res.; (United States), Vol. 34:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL STRESS
RESPONSE MODIFYING FACTORS
MANGANESE CHLORIDES
BIOLOGICAL EFFECTS
NEUROREGULATORS
BIOCHEMICAL REACTION KINETICS
RATS
GROWTH
BLOOD PLASMA
CORTICOSTERONE
DOPAMINE
EXPERIMENTAL DATA
METABOLITES
PEPTIDES
SEROTONIN
TESTOSTERONE
WEIGHT
ADRENAL HORMONES
AMINES
ANDROGENS
ANDROSTANES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHLORIDES
CHLORINE COMPOUNDS
CORTICOSTEROIDS
DATA
DRUGS
GLUCOCORTICOIDS
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
INDOLES
INFORMATION
KETONES
KINETICS
MAMMALS
MANGANESE COMPOUNDS
MANGANESE HALIDES
MATERIALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHENOLS
POLYPHENOLS
PREGNANES
PROTEINS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RODENTS
STEROID HORMONES
STEROIDS
SYMPATHOMIMETICS
TRANSITION ELEMENT COMPOUNDS
TRYPTAMINES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)