AET reduces the frequency of micronuclei in bone marrow cells of mice exposed to gamma radiation
The purpose of this paper was to determine whether or not a radioprotective agent which binds to DNA and inhibits DNA damage could also provide protection against radiation-induced micronuclei. Male mice were injected intraperitoneally with such an agent, 2-aminoethylisothiouronium bromide hydrobromide (AET), or its solvent 15 min prior to a single 10-min exposure to /sup 60/Co gamma rays delivered at various dose rates. Animals were killed 24 hr after irradiation and examined for the frequency of polychromatic erythrocytes containing micronuclei. The results showed a significant dose response to the irradiation for both treatments and a significant reduction in the frequency of micronucleated cells in the mice receiving the radioprotective agent.
- Research Organization:
- Division of Biological and Medical Research, Argonne National Laboratory, Illinois
- OSTI ID:
- 5992156
- Journal Information:
- Radiat. Res.; (United States), Vol. 93:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AET
RADIOSENSITIVITY EFFECTS
BONE MARROW CELLS
BIOLOGICAL RADIATION EFFECTS
CELL NUCLEI
COBALT 60
DNA
GAMMA RADIATION
MICE
RADIOINDUCTION
AMINES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBONIC ACID DERIVATIVES
CELL CONSTITUENTS
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DRUGS
ELECTROMAGNETIC RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RODENTS
SOMATIC CELLS
THIOUREAS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals