Chemical and toxicological characterization of residential oil burner emissions. II. Mutagenic, tumorigenic, and potential teratogenic activity
Extracts of effluents from a modern residential oil burner have been evaluated in several toxicological assay systems. Bacterial mutagens were detected in extracts from both the particulate and vapor phase emissions. Effluents from continuous operation were an order of magnitude less mutagenic than those from cyclic (5 min on, 10 min off) operations. No difference in the yield of bacterial mutagens per gram of fuel burned was found between cyclic operation under low and moderate sooting conditions. On the basis of elution behavior from alumina it appeared that the bacterial mutagens collected from high sooting effluents were more polar than those from low sooting effluent. An extract that was mutagenic in bacteria did not induce a significant increase in mutation frequency to human lymphoblasts. No evidence of tumorigenicity was observed in a limited number of newborn mice after IP injection of effluent extract when compared to historical control data. Putative nonmutagenic teratogens were detected in effluent using an attachment inhibition assay. The level of these agents was reduced in effluents from continuous oil burner operation.
- Research Organization:
- Massachusetts Institute of Technology, Cambridge
- DOE Contract Number:
- AC02-83ER60174
- OSTI ID:
- 5991591
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 73
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
EXHAUST GASES
CARCINOGEN SCREENING
MUTAGEN SCREENING
TERATOGEN SCREENING
FUEL OILS
COMBUSTION
PARTICULATES
ADENOMAS
CARCINOGENESIS
FRACTIONATION
LUNGS
LYMPHOCYTES
MICE
MUTAGENESIS
OIL BURNERS
SALMONELLA TYPHIMURIUM
TUMOR CELLS
ANIMAL CELLS
ANIMALS
BACTERIA
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BURNERS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DISEASES
FLUIDS
FUELS
GASEOUS WASTES
GASES
LEUKOCYTES
LIQUID FUELS
MAMMALS
MATERIALS
MICROORGANISMS
NEOPLASMS
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
OXIDATION
PARTICLES
PATHOGENESIS
PETROLEUM PRODUCTS
RESPIRATORY SYSTEM
RODENTS
SALMONELLA
SCREENING
SEPARATION PROCESSES
SOMATIC CELLS
THERMOCHEMICAL PROCESSES
VERTEBRATES
WASTES
020600* - Petroleum- Health & Safety