Variation in the effect of five chemical carcinogens on the plaque-forming cell response

Technical Report · Tue Mar 01 00:00:00 EST 1983

OSTI ID:5991084

Raikow, R B; OKunewick, J P; Buffo, M J; Jones, D L

The effect of five different chemical carcinogens on plaque-forming cell response was measured in order to obtain an index of their effect on humoral antibody formation in vivo. Two alkyl sulfonates: methyl methane sulfonate (MMS) and 1,3-propane sultone (PS); along with three polycyclic aromatic hydrocarbons: benzo(a)pyrene (BP); 7,12-dimethyl benzanthracene (DMBA); and 20-methylcholanthrene (MCA) were chosen for these studies. Each carcinogen was administered as a single intraperitoneal injection to SJL/J mice, and the ability of the animals to generate plaque forming cells to sheep red blood cell antigens was measured as a function of time after exposure to the carcinogen. Some suppression of this humoral immune response was observed with all of the carcinogens tested. The amount and duration of this suppression varied as a function of both the type of carcinogen and the dose. Of the five carcinogens tested only DMBA and MCA produced an immunosuppressive effect that might correlate with their reported carcinogenicity, and PS administration actually resulted in a brief immunostimulatory response during the first four days after administration.

• Research Organization: Allegheny-Singer Research Corp., Pittsburgh, PA (USA)
• DOE Contract Number: AC02-78EV04800
• OSTI ID: 5991084
• Report Number(s): DOE/EV/04800-T2; ON: DE83013380
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENS
BIOLOGICAL EFFECTS
IMMUNOSUPPRESSION
MICE
IMMUNE REACTIONS
BENZANTHRACENE
BENZOPYRENE
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
IN VIVO
METHYL METHANESULFONATE
PETROLEUM SULFONATES
POLYCYCLIC AROMATIC HYDROCARBONS
ANIMALS
AROMATICS
CONDENSED AROMATICS
DATA
ESTERS
HYDROCARBONS
INFORMATION
MAMMALS
MUTAGENS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RODENTS
SULFONATES
SULFONIC ACID ESTERS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)