External imaging of cerebral muscarinic acetylcholine receptors

Journal Article · Fri Jan 20 00:00:00 EST 1984 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.6608148· OSTI ID:5989781

Eckelman, W C; Reba, R C; Rzeszotarski, W J; Gibson, R E; Hill, T; Holman, B L; Budinger, T; Conklin, J J; Eng, R; Grissom, M P

A radioiodinated ligand that binds to muscarinic acetylcholine receptors was shown to distribute in the brain by a receptor-mediated process. With single-photon-emission imaging techniques, radioactivity was detected in the cerebrum but not in the cerebellum, whereas with a flow-limited radiotracer, radioactivity was detected in cerebrum and cerebellum. Single-photon-emission computed tomography showed good definition of the caudate putamen and cortex in man.

• Research Organization: George Washington Univ. Medical Center, Washington, DC
• OSTI ID: 5989781
• Journal Information: Science (Washington, D.C.); (United States), Vol. 223
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
IODINE 125
BIOLOGICAL LOCALIZATION
RECEPTORS
BIOCHEMICAL REACTION KINETICS
ACETYLCHOLINE
COMPARATIVE EVALUATIONS
LIGANDS
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TRACER TECHNIQUES
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AMMONIUM COMPOUNDS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
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DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ESTERS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
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550601* - Medicine- Unsealed Radionuclides in Diagnostics