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Title: Human adrenal tumor cell line SW-13 contains a natriuretic peptide receptor system that responds preferentially to ANP among various natriuretic peptides

Abstract

A new type of ANP receptor system which clearly distinguishes natriuretic peptides A and B (ANP and BNP) has been identified in the human adrenal tumor cell line SW-13 and characterized. SW-13 cells responded to nanomolar concentrations of ANP with large increases in cGMP levels but in the case of BNP, much higher concentrations were required to produce the same extent of response. This property is unique since the 140-kDa ANP receptors so far characterized do not discriminate between ANP and BNP. For comparison, various natriuretic peptide receptors were also re-characterized using the recently identified CNP.

Authors:
; ; ; ; ; ;  [1]
  1. Tokyo Institute of Technology (Japan)
Publication Date:
OSTI Identifier:
5988387
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications; (USA)
Additional Journal Information:
Journal Volume: 173:3; Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ADRENAL GLANDS; NEOPLASMS; PEPTIDES; RECEPTORS; CHEMICAL COMPOSITION; CATTLE; ENDOTHELIUM; IODINE ISOTOPES; LIGANDS; MAN; TRACER TECHNIQUES; TUMOR CELLS; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; BODY; DISEASES; DOMESTIC ANIMALS; ENDOCRINE GLANDS; GLANDS; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MEMBRANE PROTEINS; ORGANIC COMPOUNDS; ORGANS; PRIMATES; PROTEINS; RUMINANTS; TISSUES; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques; 550901 - Pathology- Tracer Techniques

Citation Formats

Mizuno, T, Katafuchi, T, Hagiwara, H, Ito, T, Kangawa, K, Matsuo, H, and Hirose, S. Human adrenal tumor cell line SW-13 contains a natriuretic peptide receptor system that responds preferentially to ANP among various natriuretic peptides. United States: N. p., 1990. Web. doi:10.1016/S0006-291X(05)80869-1.
Mizuno, T, Katafuchi, T, Hagiwara, H, Ito, T, Kangawa, K, Matsuo, H, & Hirose, S. Human adrenal tumor cell line SW-13 contains a natriuretic peptide receptor system that responds preferentially to ANP among various natriuretic peptides. United States. https://doi.org/10.1016/S0006-291X(05)80869-1
Mizuno, T, Katafuchi, T, Hagiwara, H, Ito, T, Kangawa, K, Matsuo, H, and Hirose, S. 1990. "Human adrenal tumor cell line SW-13 contains a natriuretic peptide receptor system that responds preferentially to ANP among various natriuretic peptides". United States. https://doi.org/10.1016/S0006-291X(05)80869-1.
@article{osti_5988387,
title = {Human adrenal tumor cell line SW-13 contains a natriuretic peptide receptor system that responds preferentially to ANP among various natriuretic peptides},
author = {Mizuno, T and Katafuchi, T and Hagiwara, H and Ito, T and Kangawa, K and Matsuo, H and Hirose, S},
abstractNote = {A new type of ANP receptor system which clearly distinguishes natriuretic peptides A and B (ANP and BNP) has been identified in the human adrenal tumor cell line SW-13 and characterized. SW-13 cells responded to nanomolar concentrations of ANP with large increases in cGMP levels but in the case of BNP, much higher concentrations were required to produce the same extent of response. This property is unique since the 140-kDa ANP receptors so far characterized do not discriminate between ANP and BNP. For comparison, various natriuretic peptide receptors were also re-characterized using the recently identified CNP.},
doi = {10.1016/S0006-291X(05)80869-1},
url = {https://www.osti.gov/biblio/5988387}, journal = {Biochemical and Biophysical Research Communications; (USA)},
issn = {0006-291X},
number = ,
volume = 173:3,
place = {United States},
year = {Mon Dec 31 00:00:00 EST 1990},
month = {Mon Dec 31 00:00:00 EST 1990}
}