Effect of helium-neon and infrared laser irradiation on wound healing in rabbits
We examined the biostimulating effects of helium-neon laser radiation (HeNe; 632.8 nm), pulsed infrared laser radiation (IR; 904 nm), and the two combined on skin wound healing in New Zealand white rabbits. Seventy-two rabbits received either (1) no exposure, (2) 1.65 J/cm2 HeNe, (3) 8.25 J/cm2 pulsed IR, or (4) both HeNe and IR together to one of two dorsal full-thickness skin wounds, daily, for 21 days. Wound areas were measured photographically at periodic intervals. Tissue samples were analyzed for tensile strength, and histology was done to measure epidermal thickness and cross-sectional collagen area. Significant differences were found in the tensile strength of all laser-treated groups (both the irradiated and nonirradiated lesion) compared to group 1. No differences were found in the rate of wound healing or collagen area. Epidermal growth was greater in the HeNe-lased area compared to unexposed tissue, but the difference was not significant. Thus, laser irradiation at 632.8 nm and 904 nm alone or in combination increased tensile strength during wound healing and may have released tissue factors into the systemic circulation that increased tensile strength on the opposite side as well.
- Research Organization:
- Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL (USA)
- OSTI ID:
- 5984988
- Journal Information:
- Lasers Surg. Med.; (United States), Vol. 9:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LASER RADIATION
BIOLOGICAL EFFECTS
WOUNDS
HEALING
COLLAGEN
COMPARATIVE EVALUATIONS
EPIDERMIS
HELIUM-NEON LASERS
RABBITS
SKIN
TENSILE PROPERTIES
ANIMAL TISSUES
ANIMALS
BIOLOGICAL RECOVERY
BODY
ELECTROMAGNETIC RADIATION
EPITHELIUM
GAS LASERS
INJURIES
LASERS
MAMMALS
MECHANICAL PROPERTIES
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATIONS
RECOVERY
SCLEROPROTEINS
TISSUES
VERTEBRATES
560400* - Other Environmental Pollutant Effects