Adrenergic receptor subtypes in the cerebral circulation of newborn piglets

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Am. J. Physiol.: Heart Circ. Physiol.; (United States)

OSTI ID:5982879

Wagerle, L C; Delivoria-Papadopoulos, M

The purpose of this study was to identify the ..cap alpha..-adrenergic receptor subtype mediating cerebral vasoconstriction during sympathetic nerve stimulation in the newborn piglet. The effect of ..cap alpha../sub 1/- and ..cap alpha../sub 2/-antagonists prazosin and yohimbine on the cerebrovascular response to unilateral electrical stimulation (15 Hz, 15 V) of the superior cervical sympathetic trunk was studied in 25 newborn piglets. Regional cerebral blood flow was measured with tracer microspheres. Sympathetic stimulation decreased blood flow to the ipsilateral cerebrum hippocampus, choroid plexus, and masseter muscle. ..cap alpha../sub 1/-Adrenergic receptor blockade with prazosin inhibited the sympathetic vasoconstriction in the cerebrum, hippocampus, and masseter muscle and abolished it in the choroid plexus. ..cap alpha../sub s/-Adrenergic receptor blockade with yohimbine had no effect. Following the higher dose of yohimbine, however, blood flow to all brain regions was increased by approximately two-fold, possibly due to enhanced cerebral metabolism. These data demonstrate that vascular ..cap alpha../sub 1/-adrenergic receptors mediate vasoconstriction to neuroadrenergic stimulation in cerebral resistance vessels in the newborn piglet.

• Research Organization: Univ. of Pennsylvania School of Medicine, Philadelphia (USA)
• OSTI ID: 5982879
• Journal Information: Am. J. Physiol.: Heart Circ. Physiol.; (United States), Vol. 21:6
• Country of Publication: United States
• Language: English

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SCANDIUM 46
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