Carrier-free radiolabelled metyrapones
Patent
·
OSTI ID:5982706
Disclosed is the radiohalolabelling of metyrapone (1-propanone-1,2-di-(3-pyridinyl)-2-methyl), an 11Betahydroxylase inhibitor and of related compounds to form imaging agents for the adrenal cortex. Metyrapone was selectively converted to its mono-N-oxide. 4'-Bromometyrapone was obtained therefrom by a three-step conversion. Exchange labelling of the latter gave radiolabelled metyrapone. Found suitable as imaging agents are /sup 77/Br-4-bromo-metyrapone; /sup 131/l-4-iodo-metyrapone; /sup 123/l-4-iodometyrapone and their corresponding metyrapoles. Mixtures of these also can be used as imaging agents.
- Assignee:
- EDB-85-074179
- Patent Number(s):
- US 4490350
- OSTI ID:
- 5982706
- Resource Relation:
- Patent Priority Date: Priority date 12 Apr 1982, Austria; Other Information: PAT-APPL-367372
- Country of Publication:
- United States
- Language:
- English
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· J. Nucl. Med.; (United States)
·
OSTI ID:5982706
+5 more
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
TRACER TECHNIQUES
CARRIER-FREE ISOTOPES
CHEMICAL COMPOSITION
LABELLING
RADIOPHARMACEUTICALS
ACETONE
BROMINE 77
DRUGS
HALOGENS
HYDROXYLASES
IMAGES
IODINE 123
IODINE 131
ISOTOPIC EXCHANGE
NITROGEN OXIDES
NUCLEAR MEDICINE
PYRIDINES
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BROMINE ISOTOPES
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENDOCRINE GLANDS
ENZYMES
GLANDS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
LABELLED COMPOUNDS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NITROGEN COMPOUNDS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
RADIOISOTOPES
550600* - Medicine
ADRENAL GLANDS
TRACER TECHNIQUES
CARRIER-FREE ISOTOPES
CHEMICAL COMPOSITION
LABELLING
RADIOPHARMACEUTICALS
ACETONE
BROMINE 77
DRUGS
HALOGENS
HYDROXYLASES
IMAGES
IODINE 123
IODINE 131
ISOTOPIC EXCHANGE
NITROGEN OXIDES
NUCLEAR MEDICINE
PYRIDINES
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BROMINE ISOTOPES
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENDOCRINE GLANDS
ENZYMES
GLANDS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
LABELLED COMPOUNDS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NITROGEN COMPOUNDS
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
RADIOISOTOPES
550600* - Medicine