Potential use of radiolabelled porphyrins for tumor scanning

Journal Article · Sat Jan 01 00:00:00 EST 1983 · Adv. Exp. Med. Biol.; (United States)

DOI:https://doi.org/10.1007/978-1-4684-4406-3_23· OSTI ID:5979378

Thaller, R A; Lyster, D M; Dolphin, D

Fe-TMPI, Fe-TCP and protohemins showed high initial uptake using tissue culture techniques with mouse tumor cells (P815). However, the tumor uptake in the in vivo model was poor. Of the radionuclides investigated, iron labelled to TMPI demonstrated the best uptake by tumor in vitro. As has been previously demonstrated, the unnatural meso-arylporphyrin derivatives showed better uptake than did naturally occurring porphyrins and their derivatives.

• Research Organization: Vancouver General Hospital, Department of Pharmacy, University of British Columbia, Canada
• OSTI ID: 5979378
• Journal Information: Adv. Exp. Med. Biol.; (United States), Vol. 160
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
IRON ISOTOPES
DIAGNOSTIC USES
PORPHYRINS
LABELLED COMPOUNDS
NEOPLASMS
RADIOISOTOPE SCANNING
TUMOR CELLS
ANIMAL CELLS
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
DISEASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
ISOTOPES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics