Nuclear magnetic resonance and proton relaxation times in experimental heterotopic heart transplantation

Journal Article · Wed Jan 01 00:00:00 EST 1986 · J. of Heart Transplant.; (United States)

OSTI ID:5977371

Eugene, M; Lechat, P; Hadjiisky, P; Teillac, A; Grosgogeat, Y; Cabrol, C

It should be possible to detect heart transplant rejection by nuclear magnetic resonance (NMR) imaging if it induces myocardial T1 and T2 proton relaxation time alterations or both. We studied 20 Lewis rats after a heterotopic heart transplantation. In vitro measurement of T1 and T2 was performed on a Minispec PC20 (Bruker) 3 to 9 days after transplantation. Histologic analysis allowed the quantification of rejection process based on cellular infiltration and myocardiolysis. Water content, a major determinant of relaxation time, was also studied. T1 and T2 were significantly prolonged in heterotopic vs orthotopic hearts (638 +/- 41 msec vs 606 +/- 22 msec for T1, p less than 0.01 and 58.2 +/- 8.4 msec vs 47.4 +/- 1.9 msec for T2, p less than 0.001). Water content was also increased in heterotopic hearts (76.4 +/- 2.3 vs 73.8 +/- 1.0, p less than 0.01). Most importantly, we found close correlations between T1 and especially T2 vs water content, cellular infiltration, and myocardiolysis. We conclude that rejection reaction should be noninvasively detected by NMR imaging, particularly with pulse sequences emphasizing T2.

• Research Organization: Univ. Paris VI, France
• OSTI ID: 5977371
• Journal Information: J. of Heart Transplant.; (United States), Vol. 5:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GRAFT-HOST REACTION
DIAGNOSIS
HEART
NMR IMAGING
TRANSPLANTS
MYOCARDIUM
NUCLEAR MAGNETIC RESONANCE
PROTONS
RATS
ANIMALS
BARYONS
BODY
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
ELEMENTARY PARTICLES
FERMIONS
HADRONS
MAGNETIC RESONANCE
MAMMALS
MUSCLES
NUCLEONS
ORGANS
RESONANCE
RODENTS
VERTEBRATES
550600* - Medicine