Imaging of the pancreas using dynamic positron emission tomography with N-13 ammonia

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5975922

Hayashi, N; Tamaki, N; Yonekura, Y; Adachi, H; Senda, M; Saji, H; Torizuka, K

This study was undertaken to develop a new imaging technique of the pancreas. Dynamic positron emission tomography (PET) was performed in 3 normal volunteers, 9 patient without the evidence of pancreatic diseases, 2 patients with adenocarcinoma of the pancreatic head and one patient with islet cell carcinoma. Immediately after the intravenous injection of 10-20mCi of N-13 ammonia, data were obtained every 150 seconds for 30 minutes using a multi-slice whole-body PET scanner. In two cases of adenocarcinoma, the pancreas was not imaged, probably because the nontumorous portion of the pancreas was also suffered from severe pancreatitis due to the duct obstruction at the pancreatic head. In the case with islet cell carcinoma, the radionuclide was accumulated in the tumor and pancreas similarly. Thus, both of them were visualized but not separated. The central necrosis of the tumor showed poor radioactivity. The mechanism of the radionuclide accumulation in the pancreas is not well understood. However, the authors also studied the biodistribution of N-13 ammonia in mice and confirmed that there is an early and high accumulation of the radionuclide in the murine pancreas. These preliminary results of this paper suggest that the dynamic PET study may be useful for the imaging of the pancreas as well as for the further study of the blood supply and metabolism of the pancreas.

• Research Organization: Kyoto Univ. School of Medicine, Kyoto
• OSTI ID: 5975922
• Report Number(s): CONF-850611-; TRN: 87-039217
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
AMMONIA
DIAGNOSTIC USES
LABELLING
NITROGEN 13
TISSUE DISTRIBUTION
UPTAKE
PANCREAS
METABOLISM
POSITRON COMPUTED TOMOGRAPHY
CARCINOMAS
INTRAVENOUS INJECTION
MICE
NECROSIS
NEOPLASMS
PATIENTS
RADIOISOTOPE SCANNERS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENDOCRINE GLANDS
GLANDS
HYDRIDES
HYDROGEN COMPOUNDS
INJECTION
INTAKE
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
RODENTS
TOMOGRAPHY
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques
550501 - Metabolism- Tracer Techniques