Structure-activity relationships among dithiocarbamate antidotes for acute cadmium chloride intoxication. [Mice]

Journal Article · Thu Mar 01 00:00:00 EST 1984 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8454285· OSTI ID:5975460

Jones, S G; Jones, M M

Eight sodium dithiocarbamates (NaS/sub 2/CNR/sub 1/R/sub 2/) have been examined as antidotes for acute cadmium intoxication. While all of them possess an ability to increase survival when given to mice 2 hr after a lethal (>99%) intraperitoneal injection of 10 mg/kg of CdCl/sub 2/. 2.5H/sub 2/O, their effects on the organ distribution of cadmium vary considerably. It has been possible to show that the accumulation of cadmium in the brain and kidney as well as the survival rates can be correlated with a numerical measure of the polarity of the groups R/sub 1/ and R/sub 2/. Each factor has a different dependence on the polarity, but it is possible to construct a composite factor for antidotal efficacy which incorporates survival rate, brain cadmium levels and kidney cadmium levels. The factor constructed here exhibits an optimal value approximately in the middle of the polarity range studied. Compounds which have R/sub 1/ = -CH/sub 2/CH/sub 1/OH and R/sub 2/ = -CH/sub 2/CH/sub 2/OH, OR -CH/sub 3/ or -C/sub 2/H/sub 5/ appear to be the most effective antidotes of the compounds examined. 22 references, 4 figures 3 tables.

• Research Organization: Vanderbilt Univ., Nashville, TN
• OSTI ID: 5975460
• Journal Information: Environ. Health Perspect.; (United States), Vol. 54
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
RETENTION
TOXICITY
CHELATING AGENTS
STRUCTURE-ACTIVITY RELATIONSHIPS
BRAIN
CARBAMATES
DECONTAMINATION
EXPERIMENTAL DATA
INTRAPERITONEAL INJECTION
KIDNEYS
MICE
SURVIVAL CURVES
THIOLS
ANIMALS
BODY
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CENTRAL NERVOUS SYSTEM
CLEANING
DATA
ELEMENTS
INFORMATION
INJECTION
INTAKE
MAMMALS
METALS
NERVOUS SYSTEM
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)