Effects on the development of offspring of female mice exposed to platinum sulfate or sodium hexachloroplatinate during pregnancy or lactation
On d 7 or 12 of gestation or on d 2 postpartum, Swiss ICR dams were administered either (1) a single intragastric dose of Pt(SO/sub 4/) at the LD1 level or dilute H/sub 2/SO/sub 4/ at an equivalent volume, pH, and sulfate content, or (2) a single subcutaneous dose of Na/sub 2/PtCl/sub 6/ or phosphate-buffered saline at an equivalent volume and pH. To differentiate prenatal from postnatal effects of the compounds on the offspring, a full cross-fostering design was employed. Rate of growth (as a function of weight gain) and gross activity of the neonates were assessed on d 8 or 13 postpartum. On d 60-65 postpartum, open-field behavior (ambulations and rearings), rotarod performance, and passive avoidance learning of the adult offspring were investigated. Exposure to Pt(SO/sub 4/)/sub 2/ resulted in reduced offspring weight from d 8 to 45 postpartum, whereas the major effect of Na/sub 2/PtCl/sub 6/ was a reduction in activity level of the offspring of mothers exposed on d 12 of gestation. 18 references, 2 figures, 2 tables.
- Research Organization:
- West Seneca Developmental Center, NY
- OSTI ID:
- 5971326
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 13:4-6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MICE
ANIMAL GROWTH
BEHAVIOR
PLATINUM COMPLEXES
TOXICITY
PLATINUM COMPOUNDS
EXPERIMENTAL DATA
LACTATION
NEONATES
PREGNANCY
PRENATAL EXPOSURE
SODIUM COMPOUNDS
SULFUR COMPOUNDS
ALKALI METAL COMPOUNDS
ANIMALS
COMPLEXES
DATA
GROWTH
INFORMATION
MAMMALS
NUMERICAL DATA
RODENTS
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)