Pulmonary effects of intermittent subacute exposure to low-level nitrogen dioxide

Journal Article · Sat Jan 01 00:00:00 EST 1983 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398309530354· OSTI ID:5971234

Gregory, R E; Pickrell, J A; Hahn, F F; Hobbs, C H

The pulmonary biochemical and morphological changes resulting from the inhalation of relatively low levels of NO/sub 2/ for up to 15 weeks were investigated. Specific pathogen-free Fischer 344 rats were exposed to 0, 1, or 5 ppm NO/sub 2/ or to 1 ppm with two spikes to 5 ppm NO/sub 2/ for 7 h/d, 5 d/wk for up to 15 weeks. These exposures produced a mild, concentration-related pulmonary injury, with the 5-ppm group sustaining the most damage. The other NO/sub 2/-exposed animals showed similar types of damage, although the extent was less than that observed in the 5-ppm-exposed group. After 15 weeks of exposure, histopathological examination revealed focal areas of hyperinflation and alveolar macrophage accumulation in some of the 5-ppm- and 1-5-ppm-exposed animals. These changes were preceded by a series of biochemical changes in the bronchoalveolar fluid. 19 references, 1 figure, 2 tables.

• Research Organization: Inhalation Toxicology Research Inst., Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5971234
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 11
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
INJURIES
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
AIR POLLUTION
CHRONIC EXPOSURE
EXPERIMENTAL DATA
RATS
ANIMALS
BODY
CHALCOGENIDES
DATA
INFORMATION
MAMMALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)