Four-year evaluation of workers exposed to trimellitic anhydride. A brief report
In a four-year clinical, immunologic, and environmental study of trimellitic anhydride (TMA) exposure in a single plant, 20 workers exposed to TMA powder were evaluated in 1979 and a total of 32 workers were evaluated from 1979 to 1983. Two distinct groups emerged before and after workplace control improvements were made in 1979. Seventeen of the original 20 workers were available for longitudinal study through 1983. Annual clinical evaluations and serum radioimmunoassays for total antibody binding and specific IgE binding to 125I TM-HSA (human serum albumin) were performed on all 32 workers. In 1979, six workers had antibody against TM-HSA, three had the late respiratory systemic syndrome, and two had TMA-induced allergic rhinitis or allergic rhinitis and asthma. One worker had antibody against TM-HSA without illness. Fifteen additional workers were evaluated longitudinally after institution of several workplace control measures. Four of these 15 workers had TMA exposure prior to environmental improvement and joined the study in 1982. The remaining 11 workers joined the study in 1982 and had at least two years of TMA exposure in the modified workplace. None of these 11 workers developed a TMA-induced immunologic syndrome or significant total or specific IgE antibody binding to 125I TM-HSA.
- Research Organization:
- Northwestern Univ. Medical School, Chicago, IL
- OSTI ID:
- 5970774
- Journal Information:
- JOM, J. Occup. Med.; (United States), Vol. 26:9
- Country of Publication:
- United States
- Language:
- English
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MELLITIC ACID
HEALTH HAZARDS
RESPIRATORY SYSTEM DISEASES
EPIDEMIOLOGY
ANTIBODIES
CHEMICAL BONDS
CHEMICAL PLANTS
EVALUATION
IMMUNE SERUMS
IODINE 125
LABELLED COMPOUNDS
OCCUPATIONAL EXPOSURE
PERSONNEL
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HAZARDS
IMMUNOLOGY
INDUSTRIAL PLANTS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOASSAY
RADIOISOTOPES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)