Relative activity of cerebral subcortical gray matter in varying states of attention and awareness in normal subjects and patient studies
An important aspect of the study of brain function involves measurement of the relationships; between activities in the subcortical gray matter of the caudate and of the thalamus; and between these structures and functional cortical areas. The authors have studied these relationships in 22 subjects under different conditions of activation, sleep and sensory deprivation using a PET VI system and F-18-2DG to determine regional cerebral metabolism. Subject activating conditions were maintained throughout the period of equilibration of F-18-2DG and E.E.G.'s were monitored. Multiple tomographic slices of 1-2 million counts were obtained simultaneously with slice separation of 14mm and each plane parallel to the cantho-meatal line. In activated and non-activated awake conditions for normal subjects, left and right thalmus-to-caudate ratios were similar and greater than unity. This relationship was maintained in non-REM sleep, but was reversed and divergent in REM sleep and sensory deprivation; this was also evident in 3/4 narcoleptics awake and asleep in non-REM and REM and 2/3 schizophrenics and affective disorder, subjects. This approach appears to have potential for characterizating normal and disordered regional cerebral function.
- Research Organization:
- The Univ. of Chicago, Chicago, IL
- OSTI ID:
- 5965476
- Report Number(s):
- CONF-850611-; TRN: 87-039080
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
BEHAVIOR
PHYSIOLOGY
BRAIN
BASAL METABOLISM
DYNAMIC FUNCTION STUDIES
CEREBRAL CORTEX
FLUORODEOXYGLUCOSE
METABOLISM
CEREBELLUM
CEREBRUM
DIAGNOSTIC USES
FLUORINE 18
GLUCOSE
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
SLEEP
THALAMUS
ALDEHYDES
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
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CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
USES
550101* - Behavioral Biology- Tracer Techniques
550601 - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques