Bacterial hydroxylation of codeine
Patent
·
OSTI ID:5964527
A process is described for preparing 14-hydroxycodeine which comprises: contacting codeine or a water-soluble salt thereof with bacteria of the genus Streptomyces for a period of at least about three days while the bacteria are being aerobically cultured in a rich medium in which the growth nutrients are supplied in excess and recovering 14-hydroxycodeine from the medium.
- Assignee:
- E.I. DuPont de Nemours and Co., Wilmington, DE
- Patent Number(s):
- US 4798792
- OSTI ID:
- 5964527
- Resource Relation:
- Patent File Date: Filed date 9 Sep 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
CODEINE
HYDROXYLATION
AEROBIC CONDITIONS
BACTERIA
CHEMICAL PREPARATION
GROWTH
HYDROXY COMPOUNDS
NUTRIENTS
SALTS
STREPTOMYCES
TIME DEPENDENCE
ALKALOIDS
ANALGESICS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
MICROORGANISMS
MORPHINE
NARCOTICS
OPIUM
ORGANIC COMPOUNDS
SYNTHESIS
550600* - Medicine
CODEINE
HYDROXYLATION
AEROBIC CONDITIONS
BACTERIA
CHEMICAL PREPARATION
GROWTH
HYDROXY COMPOUNDS
NUTRIENTS
SALTS
STREPTOMYCES
TIME DEPENDENCE
ALKALOIDS
ANALGESICS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
MICROORGANISMS
MORPHINE
NARCOTICS
OPIUM
ORGANIC COMPOUNDS
SYNTHESIS
550600* - Medicine