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Title: Thallium-201 imaging and estimation of residual high grade astrocytoma

Abstract

Thallium-201 brain imaging was performed on five patients as a method to differentiate persistent and/or recurrent viable Grades III and IV astrocytoma tissue from necrosis or post-therapy changes. Planar images of the head and heart were obtained in order to calculate the ratio of tumor counts to cardiac counts. The heart was chosen as the internal reference organ, as thallium uptake dynamics are reproducible under ordinary circumstances. The numerical estimation of thallium uptake in the brain tumor, expressed in terms of the tumor/cardiac index, correlated well with the clinical course in all five patients. By visual inspection, the initial computed tomographic (CT) and thallium images suggested that the tumors were approximately the same size. Follow-up thallium images were discordant with follow-up CT images. Computed tomography, in general, appeared to depict image alterations suggesting more extensive regrowth of tumor than the actual clinical status or thallium brain scans demonstrated. Histologic examination best correlated with thallium images. In one patient's course of imaging they were able to detect tumor recurrence, by means of thallium imaging, 4 months prior to its appearance on CT. When performed serially, the tumor/cardiac index may provide an estimate of residual tumor burden, which can help distinguish tumormore » recurrence from changes secondary to therapy.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Univ. of Michigan Medical Center, Ann Arbor
OSTI Identifier:
5963142
Resource Type:
Journal Article
Journal Name:
J. Nucl. Med. Technol.; (United States)
Additional Journal Information:
Journal Volume: 15:3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ASTROCYTOMAS; DIAGNOSIS; BRAIN; RADIOISOTOPE SCANNING; COMPUTERIZED TOMOGRAPHY; HISTOLOGY; IMAGES; NECROSIS; PATIENTS; THALLIUM 201; UPTAKE; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; GLIOMAS; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NEOPLASMS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Stafford-Schuck, K, Mountz, J M, McKeever, P, Taren, J, and Beierwaltes, W H. Thallium-201 imaging and estimation of residual high grade astrocytoma. United States: N. p., 1987. Web.
Stafford-Schuck, K, Mountz, J M, McKeever, P, Taren, J, & Beierwaltes, W H. Thallium-201 imaging and estimation of residual high grade astrocytoma. United States.
Stafford-Schuck, K, Mountz, J M, McKeever, P, Taren, J, and Beierwaltes, W H. 1987. "Thallium-201 imaging and estimation of residual high grade astrocytoma". United States.
@article{osti_5963142,
title = {Thallium-201 imaging and estimation of residual high grade astrocytoma},
author = {Stafford-Schuck, K and Mountz, J M and McKeever, P and Taren, J and Beierwaltes, W H},
abstractNote = {Thallium-201 brain imaging was performed on five patients as a method to differentiate persistent and/or recurrent viable Grades III and IV astrocytoma tissue from necrosis or post-therapy changes. Planar images of the head and heart were obtained in order to calculate the ratio of tumor counts to cardiac counts. The heart was chosen as the internal reference organ, as thallium uptake dynamics are reproducible under ordinary circumstances. The numerical estimation of thallium uptake in the brain tumor, expressed in terms of the tumor/cardiac index, correlated well with the clinical course in all five patients. By visual inspection, the initial computed tomographic (CT) and thallium images suggested that the tumors were approximately the same size. Follow-up thallium images were discordant with follow-up CT images. Computed tomography, in general, appeared to depict image alterations suggesting more extensive regrowth of tumor than the actual clinical status or thallium brain scans demonstrated. Histologic examination best correlated with thallium images. In one patient's course of imaging they were able to detect tumor recurrence, by means of thallium imaging, 4 months prior to its appearance on CT. When performed serially, the tumor/cardiac index may provide an estimate of residual tumor burden, which can help distinguish tumor recurrence from changes secondary to therapy.},
doi = {},
url = {https://www.osti.gov/biblio/5963142}, journal = {J. Nucl. Med. Technol.; (United States)},
number = ,
volume = 15:3,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 1987},
month = {Tue Sep 01 00:00:00 EDT 1987}
}