Biological determinants of radiation-induced human breast cancer

Journal Article · Tue Jan 01 00:00:00 EST 1980 · CRC Crit Rev Diagn Imaging; (United States)

OSTI ID:5963078

Feig, S A

This is the second in a three part series on the hypothetical risk from x-ray mammography. It will review those aspects of breast anatomy, histology, physiology, and pathology which are pertinent to radiation carcinogenesis. Radiation-induced breast cancers are histologically identical to the naturally occurring type in that they arise from the ductal epithelium and consist of a similar proportion of infiltrating and intraductal lesions. Possible explanations for the increased resistance to radiation effect in women over 30 years of age at time of exposure include regression of the glandular target tissue, hormonal changes, and parity. Examples of age-related sensitivity and hormonal dependence in other radiation-induced human and animal tumors will be discussed.

• OSTI ID: 5963078
• Journal Information: CRC Crit Rev Diagn Imaging; (United States), Vol. 13:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOMEDICAL RADIOGRAPHY
RISK ASSESSMENT
MAMMARY GLANDS
DELAYED RADIATION EFFECTS
NEOPLASMS
RADIOINDUCTION
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GLANDS
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NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIATIONS
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550602 - Medicine- External Radiation in Diagnostics- (1980-)