Promotion of lung tumors in mice
Several elements of two-stage carcinogenesis apply to the development of lung tumors in mice. At least three agents, identified as promoters, will also enhance tumor formation in lung: phorbol, saccharin, and butylated hydroxytoluene (BHT). The antioxidant BHT is effective only if animals are treated after exposure to an initiating agent. Administration can be delayed up to 5 months after urethan treatment and still enhance tumor formation. BHT enhances lung tumor formation regardless of its route of administration. The lowest dose required to produce an effect has not yet been determined. In at least one mouse strain, BHT also enhances tumor formation in animals initiated with 3-methylcholanthren or diethylnitrosaine. No evidence is available yet to show that BHT would enhance tumor development in animals treated with subcarcinogenic doses of an initiating compound. Nor has it been possible to produce more tumors with BHT in mouse strains which have a low spontaneous tumor incidence and respond poorly to urethan. Neveretheless, the data collected on the effects of BHT on mouse lung tumor development have broadened the concept of two-stage carcinogenesis and complement the evidence for initiation-promotion available for other epithelial tissues. (ERB)
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5962572
- Report Number(s):
- CONF-811057-2; ON: DE82001498
- Resource Relation:
- Conference: EPA/HERL international symposium on health effects of tumor promotion, Cincinnati, OH, USA, 13 Oct 1981
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARCINOGENESIS
TUMOR PROMOTERS
ANTIOXIDANTS
PHORBOL ESTERS
SACCHARIN
CRESOLS
LUNGS
MICE
NEOPLASMS
RESPIRATORY SYSTEM DISEASES
URETHANE
ANIMALS
AROMATICS
AZOLES
BODY
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARCINOGENS
DISEASES
ESTERS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOGENESIS
PHENOLS
PROMOTERS
RESPIRATORY SYSTEM
RODENTS
THIAZOLES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)