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Title: Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery

Abstract

2-(14C)deoxyglucose autoradiography was used to determine local cerebral glucose utilization (lCGU) in rats following chronic cocaine treatment and subsequent abstinence. lCGU was examined in 43 discrete brain regions in animals which had received daily injections of cocaine for 14 days (10 mg/kg) followed by 3 days of saline or bromocriptine (10 mg/kg) treatment. Cocaine abstinence following chronic treatment significantly reduced lCGU in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (NAc). Within the NAc, however, only the rostral pole showed significant reduction. In contrast, when bromocriptine treatment accompanied abstinence, lCGU was no longer reduced in mesocorticolimbic and most other regions, implying that metabolic recovery was enhanced by bromocriptine treatment during early abstinence following chronic cocaine treatment. These data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine.

Authors:
;  [1]
  1. Univ. of Hawaii School of Medicine, Honolulu (USA)
Publication Date:
OSTI Identifier:
5962458
Resource Type:
Journal Article
Journal Name:
Neuropsychopharmacology; (USA)
Additional Journal Information:
Journal Volume: 4:1; Journal ID: ISSN 0893-133X
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; COCAINE; BIOLOGICAL EFFECTS; ENZYME INHIBITORS; BIOCHEMICAL REACTION KINETICS; GLUCOSE; METABOLISM; AUTORADIOGRAPHY; CARBON 14 COMPOUNDS; CEREBRAL CORTEX; DOPAMINE; RATS; ALDEHYDES; ALKALOIDS; AMINES; ANESTHETICS; ANIMALS; ANTIDEPRESSANTS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; BRAIN; CARBOHYDRATES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CEREBRUM; DRUGS; HEXOSES; HYDROXY COMPOUNDS; KINETICS; LABELLED COMPOUNDS; MAMMALS; MONOSACCHARIDES; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PSYCHOTROPIC DRUGS; REACTION KINETICS; RODENTS; SACCHARIDES; SYMPATHOMIMETICS; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques

Citation Formats

Clow, D W, and Hammer, Jr, R P. Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery. United States: N. p., 1991. Web.
Clow, D W, & Hammer, Jr, R P. Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery. United States.
Clow, D W, and Hammer, Jr, R P. 1991. "Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery". United States.
@article{osti_5962458,
title = {Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery},
author = {Clow, D W and Hammer, Jr, R P},
abstractNote = {2-(14C)deoxyglucose autoradiography was used to determine local cerebral glucose utilization (lCGU) in rats following chronic cocaine treatment and subsequent abstinence. lCGU was examined in 43 discrete brain regions in animals which had received daily injections of cocaine for 14 days (10 mg/kg) followed by 3 days of saline or bromocriptine (10 mg/kg) treatment. Cocaine abstinence following chronic treatment significantly reduced lCGU in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (NAc). Within the NAc, however, only the rostral pole showed significant reduction. In contrast, when bromocriptine treatment accompanied abstinence, lCGU was no longer reduced in mesocorticolimbic and most other regions, implying that metabolic recovery was enhanced by bromocriptine treatment during early abstinence following chronic cocaine treatment. These data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine.},
doi = {},
url = {https://www.osti.gov/biblio/5962458}, journal = {Neuropsychopharmacology; (USA)},
issn = {0893-133X},
number = ,
volume = 4:1,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1991},
month = {Tue Jan 01 00:00:00 EST 1991}
}