The inverse exponential relationship between cardiac mortality and radionuclide left ventricular ejection fraction

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5961429

Kelly, M J; Kalff, V; Pitt, A

Left ventricular ejection fraction (LVEF) is a known predictor of cardiac death, and may be readily measured with radionuclide ventriculography (RVG). However the quantitative nature of the relationship of LVEF to cardiac death is not agreed. Therefore the authors prospectively followed survival in 592 consecutive adults with confirmed cardiac disease, but no other life limiting illness, in whom LVEF was measured with radionuclide ventriculography >1 year ago. The diagnosis was coronary disease (88%), cardiomyopathy (6%) or valvular disease (6%). Mean age was 56 years (range 30-81); 81% were male. Cardiac mortality/month % (CM/Mo%) was higher (P<0.001) in the 1st 2 months (Mo 1-2) than later, but did not change from the 3rd to 36th month (Mo 3-36). The relationship between CM/Mo% and LVEF is log-linear (inverse exponential). Therefore studies which dichotomise LVEF levels above or below an arbitrary value, or assume a linear relationship between cardiac mortality and LVEF, may overestimate the independent prognostic value of other variables relative to LVEF determined by RVG.

• Research Organization: Alfred Hospital, Melbourne
• OSTI ID: 5961429
• Report Number(s): CONF-850611-; TRN: 87-039244
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CARDIOVASCULAR DISEASES
DIAGNOSIS
RISK ASSESSMENT
HEART
DYNAMIC FUNCTION STUDIES
RADIOCARDIOGRAPHY
BLOOD FLOW
BLOOD VESSELS
HEART FAILURE
MORTALITY
SCINTISCANNING
SURVIVAL TIME
BODY
CARDIOGRAPHY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ORGANS
RADIOISOTOPE SCANNING
SYMPTOMS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques