Radiation dose to the respiratory airway linings from inhalation of (/sup 15/O)-carbon dioxide
Estimates of the radiation dose to the upper airways including the trachea, oropharnyx, and nasal linings from inhalation of oxygen-15 labeled CO/sub 2/ studies are provided. Three air administration procedures were examined; inhalation by nose, by mouth and by mouth through a mouthpiece. Attention is given to the inhaled radioactive gas absorbed and retained in the mucus and saliva layers lining the respiratory passages. The authors estimates from direct measurements in saliva and mucus of the highest total radiation dose is to the oropharnyx (5.2 rads, mouth; 2.8 rads, nose). The dose to the trachea was estimated to be 3.5 rads from mucus measurements from dogs. The comparative dose to lungs is 1.2 rads (Bigler and Sgouros, JNM 24:431, 1983). These doses are for steady-state measurements involving the breathing of 1 mCi/1-air for 1 hr. Single breath estimates can be obtained by dividing by the number of breaths per hr (720). Although this procedure leads to a 10% reduction in the radiation dose to the lung, the radiation dose to the lining of the vein infused is high, ranging from 70 to 430 rads for equal activity administered. The authors recommend considering the lung as the tissue at highest risk for both inhalation and IV administration procedures.
- Research Organization:
- The New York Hospital-Cornell Medical Center, New York, NY 10021
- OSTI ID:
- 5957360
- Report Number(s):
- CONF-850611-; TRN: 87-039624
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CARBON DIOXIDE
INHALATION
LABELLING
LUNG CLEARANCE
OXYGEN 15
THERAPEUTIC USES
TISSUE DISTRIBUTION
UPTAKE
RESPIRATORY SYSTEM DISEASES
THERAPY
TRACHEA
RADIATION DOSES
RADIOTHERAPY
CLEARANCE
GASES
LUNGS
MUCOUS MEMBRANES
RADIOACTIVE AEROSOLS
RADIONUCLIDE KINETICS
AEROSOLS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
COLLOIDS
DISEASES
DISPERSIONS
DISTRIBUTION
DOSES
EVEN-ODD NUCLEI
EXCRETION
FLUIDS
INTAKE
ISOTOPES
LIGHT NUCLEI
MEDICINE
MEMBRANES
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
RADIOISOTOPES
RADIOLOGY
RESPIRATORY SYSTEM
SOLS
USES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
550501 - Metabolism- Tracer Techniques