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Title: Evidence for homosexuality gene

Evidence for homosexuality gene A genetic analysis of 40 pairs of homosexual brothers has uncovered a region on the X chromosome that appears to contain a gene or genes for homosexuality. When analyzing the pedigrees of homosexual males, the researcheres found evidence that the trait has a higher likelihood of being passed through maternal genes. This led them to search the X chromosome for genes predisposing to homosexuality. The researchers examined the X chromosomes of pairs of homosexual brothers for regions of DNA that most or all had in common. Of the 40 sets of brothers, 33 shared a set of five markers in the q28 region of the long arm of the X chromosome. The linkage has a LOD score of 4.0, which translates into a 99.5% certainty that there is a gene or genes in this area that predispose males to homosexuality. The chief researcher warns, however, that this one site cannot explain all instances of homosexuality, since there were some cases where the trait seemed to be passed paternally. And even among those brothers where there was no evidence that the trait was passed paternally, seven sets of brothers did not share the Xq28 markers. It seems likely that homosexuality arises more » from a variety of causes. « less
Authors:
Publication Date:
OSTI Identifier:OSTI ID: 5957271
Resource Type:Journal Article
Resource Relation:Journal Name: Science (Washington, D.C.); (United States); Journal Volume: 261:5119
Country of Publication:United States
Language:English
Subject: 59 BASIC BIOLOGICAL SCIENCES; BEHAVIOR; GENES; HUMAN X CHROMOSOME; GENETIC MAPPING; MALES; SEX; BIOLOGICAL MARKERS; CHROMOSOMES; HETEROCHROMOSOMES; HUMAN CHROMOSOMES; MAPPING; X CHROMOSOME 550400* -- Genetics