Tc-99m red blood cells for the study of rapid hemolytic processes associated with heterologous blood transfusions
Chromium-51 labeled erythrocytes (Cr-51 RBC) are suitable for the study of hematologic disorders which involve relatively slow destruction of circulating erythrocytes, taking several days to several weeks. However, Cr-51 RBC are not suitable for investigating rapid hemolytic processes which occur within a matter of a few hours due to the variable and unpredictable elution of Cr-51 from the erythrocytes during the first 24 hours or so. Imaging, which could be useful in identifying organ systems involved in the hemolytic process, cannot be performed with Cr-51 RBC because of the high dose commitment caused by the low yield of gamma rays from Cr-51 (2). A method of labeling RBC with Tc-99m, which results in a radiopharmaceutical that combines the excellent dosimetric and imaging qualities of Tc-99m with an extremely stable bond between the Tc-99m and the RBC, is reported. The successful application of this technique in providing red cell support for a cancer patient with an unusual history of intravascular hemolytic transfusion reactions is also reported.
- Research Organization:
- Univ. of Texas Health Science Center, San Antonio
- OSTI ID:
- 5948345
- Journal Information:
- Clin. Nucl. Med.; (United States), Vol. 9:10
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pharmacologic alterations in Tc-99m binding by red blood cells: concise communication
A technique for the preparation of Tc-99m red blood cells for evaluation of gastrointestinal hemorrhage
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ERYTHROCYTES
LABELLING
HEMOLYSIS
DYNAMIC FUNCTION STUDIES
BLOOD GROUPS
CHROMIUM 51
IMMUNE REACTIONS
ISOMERIC NUCLEI
LABELLED COMPOUNDS
NEOPLASMS
PATIENTS
RADIOPHARMACEUTICALS
TECHNETIUM 99
TRACER TECHNIQUES
TRANSFUSIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM ISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LYSIS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
PATHOLOGICAL CHANGES
RADIOISOTOPES
TECHNETIUM ISOTOPES
THERAPY
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques