Antiradiation compounds XIX: metal-binding abilities of thioureas

Journal Article · Sat Sep 01 00:00:00 EDT 1984 · J. Pharm. Sci.; (United States)

DOI:https://doi.org/10.1002/jps.2600730924· OSTI ID:5948057

Foye, W O; Chao, C C

Metal-binding stability constants for a series of N- and N,N'-substituted thioureas with Cu(II), Ni(II), Al(III), and Fe(III) ions were determined by potentiometric titration. The sequence of constants for thiourea, N-methylthiourea, and N,N'-dimethylthiourea indicated steric effects of the methyl groups and that both nitrogen and sulfur were involved in the complexation. The magnitude of the constants was somewhat lower than those of the simple peptides. The mechanism of protection against ionizing radiation by thioureas is probably due to hydrogen-atom transfer rather than binding of metal ions that catalyze cellular oxidations.

• Research Organization: Massachusetts Coll. of Pharmacy and Allied Health Sciences, Boston
• OSTI ID: 5948057
• Journal Information: J. Pharm. Sci.; (United States), Vol. 73:9
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
RADIOPROTECTIVE SUBSTANCES
STABILITY
THIOUREAS
CHEMISTRY
ALUMINIUM COMPOUNDS
BINDING ENERGY
CATIONS
COPPER COMPOUNDS
IRON COMPOUNDS
NICKEL COMPOUNDS
NITROGEN
POTENTIOMETRY
SULFUR
CARBONIC ACID DERIVATIVES
CHARGED PARTICLES
DRUGS
ELEMENTS
ENERGY
IONS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
TITRATION
TRANSITION ELEMENT COMPOUNDS
400301* - Organic Chemistry- Chemical & Physicochemical Properties- (-1987)