Effect of lithium chloride on spermatogenesis and testicular steroidogenesis in mature albino rats: Duration dependent response

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90540-R· OSTI ID:5945959

Ghosh, P K; Biswas, N M; Ghosh, D ^[1]

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1. Calcutta Univ. (India)

Quantitative evaluation of the different varieties of germ cells at stage VII of the seminiferous epithelium cycle, namely type-A spermatogonia (ASg), preleptotene spermatocytes (pLSc), midpachytene spermatocytes (mPSc) and step 7 spermatids (7 Sd) along with Leydig cell nuclear area (LCNA) and radioimmunoassay of plasma levels of gonadotrophins (FSH and LH), prolactin (PRL) and testosterone (T), activities of testicular, {Delta}{sup 5}-3{beta} hydroxysteroid dehydrogenase ({Delta}{sup 5}-3{beta}-HSD) and 17{beta}-hydroxyteroid dehydrogenase (17{beta}-HSD) were measured in mature rats of the Wistar strain following treatment with lithium chloride at a dose of 200 ug/100 g body wt/day for 7, 14 and 21 days. A remarkable reduction in plasma levels of FSH, LH, PRL and T along with significant diminution in the activities of testicular {Delta}{sup 5}-3{beta}-HSD and 17 {beta}-HSD were observed following lithium treatment for 14 and 21 days. 21 days of treatment also resulted in a marked degree of degeneration of ASg and 7Sd at stage VII but 14 days of treatment did not exhibit any significant effect on testicular gametogenesis. LCNA was decreased after lithium chloride treatment for 14 and 21 days. 7 days of treatment did not exert any notable result in the above parameters.

• OSTI ID: 5945959
• Journal Information: Life Sciences; (USA), Vol. 48:7; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LITHIUM CHLORIDES
BIOLOGICAL EFFECTS
TESTES
SENSITIVITY
ENZYME ACTIVITY
FSH
LTH
OXIDOREDUCTASES
RADIOIMMUNOASSAY
RATS
SPERMATOCYTES
SPERMATOGENESIS
SPERMATOGONIA
TESTOSTERONE
ALKALI METAL COMPOUNDS
ANDROGENS
ANDROSTANES
ANIMALS
BIOASSAY
BODY
CHLORIDES
CHLORINE COMPOUNDS
DIAGNOSTIC TECHNIQUES
ENZYMES
GAMETES
GAMETOGENESIS
GERM CELLS
GONADOTROPINS
GONADS
HALIDES
HALOGEN COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KETONES
LITHIUM COMPOUNDS
LITHIUM HALIDES
MALE GENITALS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RODENTS
STEROID HORMONES
STEROIDS
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques