Thallium-201 scintigraphy in differentiated thyroid cancer: Comparison with radioiodine scintigraphy and serum thyroglobulin determinations

Journal Article · Fri Mar 01 00:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:5944193

Ramanna, L; Waxman, A; Braunstein, G ^[1]

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1. Cedars-Sinai Medical Center, Los Angeles, CA (USA)

The role of thallium-201 ({sup 201}TI) scintigraphy in the follow-up evaluation of differentiated thyroid carcinoma (DTC) is controversial. Desirable characteristics of {sup 201}TI scintigraphy including the potential for no thyroid hormone withdrawal, immediate imaging postinjection, and low radiation burden relative to iodine-131 ({sup 131}I) suggests it is logistically superior to {sup 131}I scintigraphy. Fifty-two patients with DTC were evaluated with {sup 201}TI and {sup 131}I neck and chest images, and serum thyroglobulin measurements. In post-thyroidectomy and pre-{sup 131}I ablation therapy patients, very little {sup 201}TI accumulation was noted within the thyroid bed, with discordantly increased {sup 131}I activity and normal serum thyroglobulin measurements. Twenty-nine percent of patients evaluated after {sup 131}I ablative therapy had elevated serum thyroglobulin levels and localized neck and chest abnormalities on 201TI scan that were not seen on {sup 131}I studies. Our data suggest that {sup 201}TI is more sensitive than {sup 131}I diagnostic (5 mCi) studies for detection of DTC, while {sup 131}I is more sensitive in detecting normal residual thyroid tissue postoperatively.

• OSTI ID: 5944193
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 32:3; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
DIAGNOSIS
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
THYROGLOBULIN
BIOSYNTHESIS
THYROID
IODINE 131
PATIENTS
SCINTISCANNING
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ENDOCRINE GLANDS
GLANDS
GLOBULINS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SYNTHESIS
550601* - Medicine- Unsealed Radionuclides in Diagnostics