Cerebral circulation, metabolism, and blood-brain barrier of rats in hypocapnic hypoxia
The effects of hypoxic hypoxia on physiological variables, cerebral circulation, cerebral metabolism, and blood-brain barrier were investigated in conscious, spontaneously breathing rats by exposing them to an atmosphere containing 7% O/sub 2/. Hypoxia affected a marked hypotension, hypocapnia and alkalosis. Cortical tissue high-energy phosphates and glucose content were not affected by hypoxia, glucose 6-phosphate lactate, and pyruvate levels were significantly increased. Blood-brain barrier permeability, regional brain glucose content and lumped constant were not changed by hypoxia. Local cerebral glucose utilization (LCGU) rose by 40-70% of control values in gray matter and by 80-90% in white matter. Under hypoxia, columns of increased and decreased LCGU and were detectable in cortical gray matter. Color-coded (/sup 14/C)2-deoxy-D-glucose autoradiograms of rat brain are shown. Local cerebral blood flow (LCBF) increased by 50-90% in gray matter and by up to 180% in white matter. Coupling between LCGU and LCBF in hypoxia remained unchanged. The data suggests a stimulation of glycolysis, increased glucose transport into the cell, and increased hexokinase activity. The physiological response of gray and white matter to hypoxia obviously differs. Uncoupling of the relation between LCGU and LCBF does not occur.
- Research Organization:
- Philipps-Universitaet, Marburg, West Germany
- OSTI ID:
- 5940621
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 252:3
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ANOXIA
BIOLOGICAL EFFECTS
BLOOD-BRAIN BARRIER
PERMEABILITY
BRAIN
AUTORADIOGRAPHY
BLOOD CIRCULATION
CARBON 14 COMPOUNDS
CEREBRUM
GLUCOSE
HYPOTENSION
METABOLISM
PHOSPHATES
PHYSIOLOGY
RATS
ALDEHYDES
ANIMALS
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
HEXOSES
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
RODENTS
SACCHARIDES
VERTEBRATES
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