Skeletal muscle blood flow measured by Rb-82 during changes in plasma glucose
The purpose of this work was to assess the feasibility of measuring skeletal muscle blood flow with the K+ analogue Rb-82. Flow measurements were made in the thigh muscle of anesthetized rabbits after simultaneous sortic injection of radiolabeled microspheres (15..mu..m diam) and a bolus of Rb-82. Estimates of flow as determined by Rb-82 were based on peak tissue uptake and arterial concentration achieved over 150 sc post injection and the assumption that the extraction fraction of Rb-82 in resting muscle is unity. No significant difference was found between the microsphere and Rb-82 methods. Flow estimates were an average of 18% higher with the Rb-82 method. However, the rubidium method showed less variability since the ratio of standard deviation to the mean flow ranged from .23 to .46 compared to a ratio of .47 to .56 for the microsphere method. The values for mean flow and its variability are consistent with previously published reports on blood flow measurements in the resting skeletal muscle of the anesthetized rabbit. This study suggests that valid measurements of skeletal muscle blood flow can be made using positron emitting radionuclides.
- Research Organization:
- Div. of Cardiology, Dept. of Medicine, Univ. of Texas Health Science Center, Houston, TX
- OSTI ID:
- 5939130
- Report Number(s):
- CONF-850611-; TRN: 87-039260
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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BLOOD FLOW
RADIOISOTOPE SCANNING
MUSCLES
RUBIDIUM 82
DIAGNOSTIC USES
BLOOD PLASMA
GLUCOSE
MONITORING
POSITRON COMPUTED TOMOGRAPHY
SCINTISCANNING
VARIATIONS
ALDEHYDES
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOHYDRATES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEXOSES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
RUBIDIUM ISOTOPES
SACCHARIDES
TOMOGRAPHY
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics