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Title: Bone scintigraphy in fluoride treated osteoporosis

Abstract

Quantitative bone scintigraphy was performed on 23 white females with post-menopausal osteoporosis and vertebral compression fractures. These patients were then entered into a randomized, double-blind clinical trial or sodium fluoride therapy (NaF=14, placebo=9) which included repeat bone scintigraphy every six months. Scintigraphic images were acquired for 500K counts per image over the total body with computer acquisition over the posterior thoracic and lumbar spine. Images were obtained on a wide field-of-view gamma camera two hours after injecting 15 mCi of Tc-99m MDP. Data analysis showed a significant reduction in the activity ratio of abnormal vertebral body to normal vertebral body in those patients treated with sodium fluoride (paired t-test p=0.0095). No significant change was observed in the control group of (p=0.142). These results suggest that sodium fluoride therapy promotes more rapid healing of osteoporotic vertebral fractures. They also demonstrate the utility of serial quantitative bone scintigraphy in assessing osteoporotic patients with vertebral compression fractures.

Authors:
; ;
Publication Date:
Research Org.:
Henry Ford Hospital, Detroit, MI
OSTI Identifier:
5938849
Report Number(s):
CONF-850611-
Journal ID: CODEN: JNMEA; TRN: 87-039277
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; BONE FRACTURES; CHEMOTHERAPY; HEALING; BONE TISSUES; SCINTISCANNING; OSTEOPOROSIS; SODIUM FLUORIDES; THERAPEUTIC USES; DATA ACQUISITION SYSTEMS; DATA ANALYSIS; FEMALES; IMAGE PROCESSING; PATIENTS; ALKALI METAL COMPOUNDS; ANIMAL TISSUES; BIOLOGICAL RECOVERY; BODY; CONNECTIVE TISSUE; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; FLUORIDES; FLUORINE COMPOUNDS; HALIDES; HALOGEN COMPOUNDS; INJURIES; PROCESSING; RADIOISOTOPE SCANNING; RECOVERY; SKELETAL DISEASES; SODIUM COMPOUNDS; THERAPY; TISSUES; USES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 551000 - Physiological Systems; 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Froelich, J W, Kleerekoper, M, and Parker, D A. Bone scintigraphy in fluoride treated osteoporosis. United States: N. p., 1985. Web.
Froelich, J W, Kleerekoper, M, & Parker, D A. Bone scintigraphy in fluoride treated osteoporosis. United States.
Froelich, J W, Kleerekoper, M, and Parker, D A. 1985. "Bone scintigraphy in fluoride treated osteoporosis". United States.
@article{osti_5938849,
title = {Bone scintigraphy in fluoride treated osteoporosis},
author = {Froelich, J W and Kleerekoper, M and Parker, D A},
abstractNote = {Quantitative bone scintigraphy was performed on 23 white females with post-menopausal osteoporosis and vertebral compression fractures. These patients were then entered into a randomized, double-blind clinical trial or sodium fluoride therapy (NaF=14, placebo=9) which included repeat bone scintigraphy every six months. Scintigraphic images were acquired for 500K counts per image over the total body with computer acquisition over the posterior thoracic and lumbar spine. Images were obtained on a wide field-of-view gamma camera two hours after injecting 15 mCi of Tc-99m MDP. Data analysis showed a significant reduction in the activity ratio of abnormal vertebral body to normal vertebral body in those patients treated with sodium fluoride (paired t-test p=0.0095). No significant change was observed in the control group of (p=0.142). These results suggest that sodium fluoride therapy promotes more rapid healing of osteoporotic vertebral fractures. They also demonstrate the utility of serial quantitative bone scintigraphy in assessing osteoporotic patients with vertebral compression fractures.},
doi = {},
url = {https://www.osti.gov/biblio/5938849}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 26:5,
place = {United States},
year = {Wed May 01 00:00:00 EDT 1985},
month = {Wed May 01 00:00:00 EDT 1985}
}

Conference:
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