Gastric emptying abnormalities in progressive systemic sclerosis
The authors studied gastric emptying (GE) in patients with peripheral manifestations of progressive systemic sclerosis (PSS) using a radionuclide method. 18 patients underwent esophageal manometry and a GE study using chicken liver labeled in vivo with Tc-99m sulfur colloid as a marker of solid emptying. GE was also measured in 13 normal volunteers. 4 PSS patients with normal esophageal motility also had normal GE. The GE of 14 PSS patients with abnormal esophageal motility was significantly (p < 0.05) delayed; with 67.4% retention of isotope after 2 hours compared to 49.8 in normals. The authors conclude that GE of solids is slow in approximately 2/3 of PSS patients with abnormal esophageal motility but is normal if the esophagus is uninvolved; Delayed GE may contribute to the severity of gastroesophageal reflux in PSS patients and the degree of dysphasgia; and Metoclopramide accelerates GE in PSS patients and should have a valuable therapeutic role.
- Research Organization:
- Yale Univ., New Haven, CT
- OSTI ID:
- 5938378
- Report Number(s):
- CONF-850611-; TRN: 87-039309
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Abnormalities of esophageal and gastric emptying in progressive systemic sclerosis
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59 BASIC BIOLOGICAL SCIENCES
AMIDES
BIOLOGICAL EFFECTS
DIGESTION
INHIBITION
STOMACH
DYNAMIC FUNCTION STUDIES
COLLOIDS
DIGESTIVE SYSTEM DISEASES
DRUGS
ESOPHAGUS
ISCHEMIA
TECHNETIUM 99
THERAPEUTIC USES
UPTAKE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
TECHNETIUM ISOTOPES
USES
VASCULAR DISEASES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques