TCDD (2,3,7,8-tetrachlorodibenzo-P-dioxin) reduces lipoprotein lipase activity in the adipose tissue of the guinea pig
Abstract
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) adminstered to young male guinea pigs at a dose of 1 ..mu..g/kg (single intraperitoneal injection) caused a large reduction in adipose tissue lipoprotein lipase (LPL) activity. This effect occurred rapidly; a 70% decrease was noticed after 24 hour and 80% of LPL activity was lost by 48 hours when the serum triglyceride levels increased to 175% of control levels. LPL is known to play an important role in controlling the amount of free fatty acids supplied to adipose tissues. Administration of a large dose of glucose to fasted guinea pigs, which have shown a similar weight loss, but less LPL loss than TCDD-treated animals, had the effect of elevating their adipose LPL levels back to a near normal level, whereas the same treatment caused no significant increase in the LPL levels of TCDD-treated animals. Evidence indicates that the TCDD-caused decline in LPL activity is irreversible. As a consequence, the affected guinea pigs are incapable of responding to changes in nutritional status. 36 references, 2 figures, 1 table.
- Authors:
- Publication Date:
- Research Org.:
- Michigan State Univ., East Lansing
- OSTI Identifier:
- 5934560
- Resource Type:
- Journal Article
- Journal Name:
- Biochem. Biophys. Res. Commun.; (United States)
- Additional Journal Information:
- Journal Volume: 122:2
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DIOXIN; BIOLOGICAL EFFECTS; LIPASE; ENZYME ACTIVITY; ADIPOSE TISSUE; CARBOXYLIC ACIDS; GUINEA PIGS; NUTRIENTS; TRIGLYCERIDES; ANIMAL TISSUES; ANIMALS; BODY; CARBOXYLESTERASES; CONNECTIVE TISSUE; ENZYMES; ESTERASES; ESTERS; HETEROCYCLIC COMPOUNDS; HYDROLASES; LIPIDS; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; RODENTS; TISSUES; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
Citation Formats
Brewster, D W, and Matsumura, F. TCDD (2,3,7,8-tetrachlorodibenzo-P-dioxin) reduces lipoprotein lipase activity in the adipose tissue of the guinea pig. United States: N. p., 1984.
Web. doi:10.1016/S0006-291X(84)80106-0.
Brewster, D W, & Matsumura, F. TCDD (2,3,7,8-tetrachlorodibenzo-P-dioxin) reduces lipoprotein lipase activity in the adipose tissue of the guinea pig. United States. https://doi.org/10.1016/S0006-291X(84)80106-0
Brewster, D W, and Matsumura, F. 1984.
"TCDD (2,3,7,8-tetrachlorodibenzo-P-dioxin) reduces lipoprotein lipase activity in the adipose tissue of the guinea pig". United States. https://doi.org/10.1016/S0006-291X(84)80106-0.
@article{osti_5934560,
title = {TCDD (2,3,7,8-tetrachlorodibenzo-P-dioxin) reduces lipoprotein lipase activity in the adipose tissue of the guinea pig},
author = {Brewster, D W and Matsumura, F},
abstractNote = {TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) adminstered to young male guinea pigs at a dose of 1 ..mu..g/kg (single intraperitoneal injection) caused a large reduction in adipose tissue lipoprotein lipase (LPL) activity. This effect occurred rapidly; a 70% decrease was noticed after 24 hour and 80% of LPL activity was lost by 48 hours when the serum triglyceride levels increased to 175% of control levels. LPL is known to play an important role in controlling the amount of free fatty acids supplied to adipose tissues. Administration of a large dose of glucose to fasted guinea pigs, which have shown a similar weight loss, but less LPL loss than TCDD-treated animals, had the effect of elevating their adipose LPL levels back to a near normal level, whereas the same treatment caused no significant increase in the LPL levels of TCDD-treated animals. Evidence indicates that the TCDD-caused decline in LPL activity is irreversible. As a consequence, the affected guinea pigs are incapable of responding to changes in nutritional status. 36 references, 2 figures, 1 table.},
doi = {10.1016/S0006-291X(84)80106-0},
url = {https://www.osti.gov/biblio/5934560},
journal = {Biochem. Biophys. Res. Commun.; (United States)},
number = ,
volume = 122:2,
place = {United States},
year = {Tue Jul 31 00:00:00 EDT 1984},
month = {Tue Jul 31 00:00:00 EDT 1984}
}