Metabolism of 18S rRNA in rat liver cells in different functional states of protein-synthesizing apparatus
Journal Article
·
· Biochemistry (Engl. Transl.); (United States)
OSTI ID:5933074
The ratio of the absolute radioactivities of 28S and 18S RNAs in the fractions of membrane-bound and free polysomes and the fraction of free rat liver ribosomes was studied under conditions of inhibition of translation by cycloheximide, insulin, and cAMP. It was found that insulin and cAMP, in contrast to cycloheximide, do not induce selective degradation of 18S rRNA. The results are discussed from the standpoint of the possible role of the phosphorylation of protein S6 in the degradation of the 40S ribosomal subunit.
- Research Organization:
- Institute of Chemical Physics, Chernogolovka, USSR
- OSTI ID:
- 5933074
- Journal Information:
- Biochemistry (Engl. Transl.); (United States), Vol. 50:10; Other Information: Translated from Biokhimiya; 50: No. 10, 1587-1590(Oct 1985)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
RNA
BIODEGRADATION
BIOSYNTHESIS
METABOLISM
RADIOASSAY
AMP
BIOLOGICAL EFFECTS
CARBON 14 COMPOUNDS
COMPARATIVE EVALUATIONS
CYCLOHEXIMIDE
INHIBITION
INSULIN
LABELLING
LIVER CELLS
OROTIC ACID
PHOSPHORUS 32
PHOSPHORYLATION
PROTEINS
RATS
RIBOSOMES
SCINTILLATION COUNTING
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHEMICAL REACTIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
DISTRIBUTION
DRUGS
FUNGICIDES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
NUCLEI
NUCLEIC ACIDS
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
PEPTIDE HORMONES
PESTICIDES
PHOSPHORUS ISOTOPES
PYRIMIDINES
RADIOISOTOPES
RODENTS
SOMATIC CELLS
SYNTHESIS
URACILS
VERTEBRATES
550501* - Metabolism- Tracer Techniques
550301 - Cytology- Tracer Techniques
RNA
BIODEGRADATION
BIOSYNTHESIS
METABOLISM
RADIOASSAY
AMP
BIOLOGICAL EFFECTS
CARBON 14 COMPOUNDS
COMPARATIVE EVALUATIONS
CYCLOHEXIMIDE
INHIBITION
INSULIN
LABELLING
LIVER CELLS
OROTIC ACID
PHOSPHORUS 32
PHOSPHORYLATION
PROTEINS
RATS
RIBOSOMES
SCINTILLATION COUNTING
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHEMICAL REACTIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
DISTRIBUTION
DRUGS
FUNGICIDES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
NUCLEI
NUCLEIC ACIDS
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
PEPTIDE HORMONES
PESTICIDES
PHOSPHORUS ISOTOPES
PYRIMIDINES
RADIOISOTOPES
RODENTS
SOMATIC CELLS
SYNTHESIS
URACILS
VERTEBRATES
550501* - Metabolism- Tracer Techniques
550301 - Cytology- Tracer Techniques