Effects of lead acetate on guinea pig - cochear microphonics, action potential, and motor nerve conduction velocity
Segmental demyelination and axonal degeneration of motor nerves induced by lead exposure is well known in man, and animals. The effect of lead acetate exposure to man may involve the cranial nerves, since vertigo and sensory neuronal deafness have been reported among lead workers. However, there are few reports concerning the dose-effects of lead acetate both to the peripheral nerve and the cranial VII nerve with measurement of blood lead concentration. The authors investigated the effects of lead acetate to the cochlea and the VIII nerve using CM (cochlear microphonics) and AP (action potential) of the guinea pigs. The effects of lead acetate to the sciatic nerve were measured by MCV of the sciatic nerve with measurement of blood lead concentration.
- Research Organization:
- Asahikawa Medical College, Hokkaido, Japan
- OSTI ID:
- 5932566
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 38:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LEAD COMPOUNDS
BLOOD CHEMISTRY
SCIATIC NERVE
BIOELECTRICITY
ACETATES
DOSE-RESPONSE RELATIONSHIPS
GUINEA PIGS
PHYSIOLOGY
VELOCITY
ANIMALS
CARBOXYLIC ACID SALTS
ELECTRICITY
MAMMALS
NERVES
NERVOUS SYSTEM
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology