Percutaneous transluminal coronary angioplasty in patients with reduced left ventricular ejection fraction: Effects on myocardial perfusion and left ventricular response to exercise

Singh, A; Chandler, S; Pears, D; Perry, R; Murray, R G; Shiu, M F

doi:10.1002/clc.4960120504

Title: Percutaneous transluminal coronary angioplasty in patients with reduced left ventricular ejection fraction: Effects on myocardial perfusion and left ventricular response to exercise

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Abstract

Many patients with coronary artery disease treated by percutaneous transluminal coronary angioplasty (PTCA) have a history of previous myocardial injury resulting in a reduced left ventricular ejection fraction (EF). The effects of successful PTCA on myocardial perfusion and left ventricular function in these patients were compared to treatment in patients with normal left ventricular EF. There were 21 patients with a normal EF (mean EF 59 +/- 2%) (Group I) and 15 patients with reduced EF (mean EF 43 +/- 1%) (Group II). Before PTCA a similar degree of reversible myocardial ischemia was present on thallium scintigraphy. At peak exercise left ventricular EF in the Group I patients decreased by 4 +/- 1% compared to 8 +/- 1% in Group II. At one month following successful PTCA there was resolution of reversible myocardial ischemia in both groups. No changes in EF at rest were observed. At the same level of exercise as before PTCA the mean EF was 5 +/- 1% higher than the pretreatment value in Group I and 10 +/- 1% higher in Group II. Thus in this study reversible myocardial ischemia was associated with severe compromise in the left ventricular response to exercise which was substantially improvedmore » by PTCA.« less

Authors:: Singh, A; Chandler, S; Pears, D; Perry, R; Murray, R G; Shiu, M F

Publication Date:: Mon May 01 00:00:00 EDT 1989

Research Org.:: Univ. Department of Cardiovascular Medicine, Birmingham (England)

OSTI Identifier:: 5931634

Resource Type:: Journal Article

Journal Name:: Clin. Cardiol.; (United States)

Additional Journal Information:: Journal Volume: 12:5

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; HEART; SCINTISCANNING; ISCHEMIA; DIAGNOSIS; BLOOD CIRCULATION; EXERCISE; PATIENTS; SURGERY; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; MEDICINE; ORGANS; RADIOISOTOPE SCANNING; VASCULAR DISEASES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550600 - Medicine

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                    Singh, A, Chandler, S, Pears, D, Perry, R, Murray, R G, and Shiu, M F. Percutaneous transluminal coronary angioplasty in patients with reduced left ventricular ejection fraction: Effects on myocardial perfusion and left ventricular response to exercise.  United States: N. p., 1989. 
        Web.  doi:10.1002/clc.4960120504.

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                    Singh, A, Chandler, S, Pears, D, Perry, R, Murray, R G, & Shiu, M F. Percutaneous transluminal coronary angioplasty in patients with reduced left ventricular ejection fraction: Effects on myocardial perfusion and left ventricular response to exercise.  United States.  https://doi.org/10.1002/clc.4960120504

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                    Singh, A, Chandler, S, Pears, D, Perry, R, Murray, R G, and Shiu, M F. 1989.  
        "Percutaneous transluminal coronary angioplasty in patients with reduced left ventricular ejection fraction: Effects on myocardial perfusion and left ventricular response to exercise".  United States.  https://doi.org/10.1002/clc.4960120504.

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@article{osti_5931634,

  title        = {Percutaneous transluminal coronary angioplasty in patients with reduced left ventricular ejection fraction: Effects on myocardial perfusion and left ventricular response to exercise},

  author       = {Singh, A and Chandler, S and Pears, D and Perry, R and Murray, R G and Shiu, M F},

  abstractNote = {Many patients with coronary artery disease treated by percutaneous transluminal coronary angioplasty (PTCA) have a history of previous myocardial injury resulting in a reduced left ventricular ejection fraction (EF). The effects of successful PTCA on myocardial perfusion and left ventricular function in these patients were compared to treatment in patients with normal left ventricular EF. There were 21 patients with a normal EF (mean EF 59 +/- 2%) (Group I) and 15 patients with reduced EF (mean EF 43 +/- 1%) (Group II). Before PTCA a similar degree of reversible myocardial ischemia was present on thallium scintigraphy. At peak exercise left ventricular EF in the Group I patients decreased by 4 +/- 1% compared to 8 +/- 1% in Group II. At one month following successful PTCA there was resolution of reversible myocardial ischemia in both groups. No changes in EF at rest were observed. At the same level of exercise as before PTCA the mean EF was 5 +/- 1% higher than the pretreatment value in Group I and 10 +/- 1% higher in Group II. Thus in this study reversible myocardial ischemia was associated with severe compromise in the left ventricular response to exercise which was substantially improved by PTCA.},

  doi          = {10.1002/clc.4960120504},

  url          = {https://www.osti.gov/biblio/5931634},
  journal      = {Clin. Cardiol.; (United States)},
number       = ,

  volume       = 12:5,

  place        = {United States},

  year         = {Mon May 01 00:00:00 EDT 1989},

  month        = {Mon May 01 00:00:00 EDT 1989}

}

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