Statistical association between cancer incidence and major-cause mortality, and estimated residential exposure to air emissions from petroleum and chemical plants
An ecologic study design was used to investigate the relationship between exposure to air emissions produced by the petroleum and chemical industries, and average annual cancer incidence and major cause mortality rates among whites in Contra Costa County, California. Estimates for the exposure to major industrial sources of sulfur dioxide, hydrocarbons and oxides of nitrogen were used to subdivide the county by level of exposure to petroleum refinery and chemical plant emissions. Cancer incidence and major cause mortality rates were then calculated for whites in each of the exposure areas. In both males and females, residential exposure to petroleum and chemical air emissions was associated with an increased incidence of cancer of the buccal cavity and pharynx. In males, age-adjusted incidence rates for cancers of the stomach, lung, prostate and kidney and urinary organs were also associated with petroleum and chemical plant air emission exposures. In both sexes, a strong positive association was found between degree of residential exposure and death rates from cardiovascular disease and cancer, and a less strong positive association between exposure and death rates from cerebrovascular disease. There was also a positive association in men for deaths from cirrhosis of the liver. Although these observed associations occurred across areas of similar socioeconomic and broad occupational class, confounding variables and the ecologic fallacy must be considered as possible explanations. In particular, the strong findings in men suggest an occupational explanation of the cancer incidence trends, and the effect observed in cirrhosis mortality suggests that lifestyle variables such as alcohol consumption were not adequately controlled for. 26 references, 1 figure, 6 tables.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- OSTI ID:
- 5927748
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 54
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AIR POLLUTION
HEALTH HAZARDS
CHEMICAL INDUSTRY
LIVER CIRRHOSIS
DISEASE INCIDENCE
NEOPLASMS
PETROLEUM INDUSTRY
VASCULAR DISEASES
CALIFORNIA
CORRELATIONS
DATA ANALYSIS
EPIDEMIOLOGY
HYDROCARBONS
INDUSTRIAL PLANTS
KIDNEYS
LIFE STYLES
LUNGS
MORTALITY
NITROGEN OXIDES
OCCUPATIONAL EXPOSURE
PROSTATE
STATISTICAL DATA
STOMACH
SULFUR DIOXIDE
URINARY TRACT
BODY
CHALCOGENIDES
DATA
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
FEDERAL REGION IX
GASTROINTESTINAL TRACT
GLANDS
HAZARDS
INDUSTRY
INFORMATION
MALE GENITALS
NITROGEN COMPOUNDS
NORTH AMERICA
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
SULFUR COMPOUNDS
SULFUR OXIDES
USA
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)