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Title: High-resolution PET studies in Alzheimer's disease

Abstract

Forty-seven patients with probable dementia of the Alzheimer type (DAT) and 30 healthy age-matched controls were scanned using (18F)-2-fluoro-2-deoxy-D-glucose on a Scanditronix PC 1024-7B tomograph (inplane resolution = 6 mm, axial resolution = 10 mm). Patients and controls were scanned in the resting state with their eyes patched and ears occluded. The regional cerebral metabolic rates for glucose (rCMRglc) in most major neocortical and subcortical gray matter regions, and certain metabolic ratios (rCMRglc/ calcarine rCMRglc), quantitatively discriminated even the mildly demented patients from healthy controls. The association neocortices showed metabolic abnormalities that were more severe than those in the sensorimotor and calcarine regions. All demented groups showed significant neuropsychological disturbances when compared to healthy controls. These data demonstrated widespread metabolic disturbances, particularly in the association areas, relatively early in Alzheimer's disease, and more profound involvement with disease progression.

Authors:
; ; ; ; ; ; ;  [1]
  1. National Institutes of Health, Bethesda, MD (USA)
Publication Date:
OSTI Identifier:
5919253
Resource Type:
Journal Article
Journal Name:
Neuropsychopharmacology; (USA)
Additional Journal Information:
Journal Volume: 4:1; Journal ID: ISSN 0893-133X
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; POSITRON COMPUTED TOMOGRAPHY; GLUCOSE; METABOLISM; NERVOUS SYSTEM DISEASES; DIAGNOSIS; FLUORINE 18; PATIENTS; ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MONOSACCHARIDES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; SACCHARIDES; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Kumar, A, Schapiro, M B, Grady, C, Haxby, J V, Wagner, E, Salerno, J A, Friedland, R P, and Rapoport, S I. High-resolution PET studies in Alzheimer's disease. United States: N. p., 1991. Web.
Kumar, A, Schapiro, M B, Grady, C, Haxby, J V, Wagner, E, Salerno, J A, Friedland, R P, & Rapoport, S I. High-resolution PET studies in Alzheimer's disease. United States.
Kumar, A, Schapiro, M B, Grady, C, Haxby, J V, Wagner, E, Salerno, J A, Friedland, R P, and Rapoport, S I. 1991. "High-resolution PET studies in Alzheimer's disease". United States.
@article{osti_5919253,
title = {High-resolution PET studies in Alzheimer's disease},
author = {Kumar, A and Schapiro, M B and Grady, C and Haxby, J V and Wagner, E and Salerno, J A and Friedland, R P and Rapoport, S I},
abstractNote = {Forty-seven patients with probable dementia of the Alzheimer type (DAT) and 30 healthy age-matched controls were scanned using (18F)-2-fluoro-2-deoxy-D-glucose on a Scanditronix PC 1024-7B tomograph (inplane resolution = 6 mm, axial resolution = 10 mm). Patients and controls were scanned in the resting state with their eyes patched and ears occluded. The regional cerebral metabolic rates for glucose (rCMRglc) in most major neocortical and subcortical gray matter regions, and certain metabolic ratios (rCMRglc/ calcarine rCMRglc), quantitatively discriminated even the mildly demented patients from healthy controls. The association neocortices showed metabolic abnormalities that were more severe than those in the sensorimotor and calcarine regions. All demented groups showed significant neuropsychological disturbances when compared to healthy controls. These data demonstrated widespread metabolic disturbances, particularly in the association areas, relatively early in Alzheimer's disease, and more profound involvement with disease progression.},
doi = {},
url = {https://www.osti.gov/biblio/5919253}, journal = {Neuropsychopharmacology; (USA)},
issn = {0893-133X},
number = ,
volume = 4:1,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1991},
month = {Tue Jan 01 00:00:00 EST 1991}
}