Hemimegalencephaly: Clinical, EEG, neuroimaging, and IMP-SPECT correlation

Journal Article · Thu Nov 01 00:00:00 EST 1990 · Pediatric Neurology; (USA)

DOI:https://doi.org/10.1016/0887-8994(90)90011-O· OSTI ID:5919194

Konkol, R J; Maister, B H; Wells, R G; Sty, J R ^[1]

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1. Medical College of Wisconsin, Milwaukee (USA)

Iofetamine-single photon emission computed tomography (IMP-SPECT) was performed on 2 girls (5 1/2 and 6 years of age) with histories of intractable seizures, developmental delay, and unilateral hemiparesis secondary to hemimegalencephaly. Electroencephalography (EEG) revealed frequent focal discharges in 1 patient, while a nearly continuous burst suppression pattern over the malformed hemisphere was recorded in the other. IMP-SPECT demonstrated a good correlation with neuroimaging studies. In spite of the different EEG patterns, which had been proposed to predict contrasting clinical outcomes, both IMP-SPECT scans disclosed a similar decrease in tracer uptake in the malformed hemisphere. These results are consistent with the pattern of decreased tracer uptake found in other interictal studies of focal seizures without cerebral malformations. In view of recent recommendations for hemispherectomy in these patients, we suggest that the IMP-SPECT scan be used to compliment EEG as a method to define the extent of abnormality which may be more relevant to long-term prognosis than EEG alone.

• OSTI ID: 5919194
• Journal Information: Pediatric Neurology; (USA), Vol. 6:6; ISSN 0887-8994
• Country of Publication: United States
• Language: English

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