Site of deposition and factors affecting clearance of aerosolized solute from canine lungs
The influence of several factors on lung solute clearance using aerosolized /sup 99m/Tc-diethylenetriaminepentaacetate was determined. The authors used a jet nebulizer-plate separator-balloon system to generate particles with an activity median aerodynamic diameter of 1.1 ..mu..m, administered the aerosol in a standard fashion, and determined clearance half times (t/sub 1/2/) with a gamma-scintillation camera. The following serial studies were performed in five anesthetized, paralyzed, intubated, mechanically ventilated dogs: (1) control, with ventilatory frequency (f) = 15 breaths/min and tidal volume (V/sub T/) = 15 ml/kg during solute clearance; (2) repeat control, for reproducibility; (3) increased frequency, with f = 25 breaths/min and V/sub T/ = 10 ml/kg; (4) positive end-expiratory pressure (PEEP) of 10 cmH/sub 2/O; (5) unilateral pulmonary arterial occlusion (PAO); and (6) bronchial arterial occlusion (BAO). Control t/sub 1/2/ was 25 +/- 5 min and did not change in the repeat control, increased frequency, or BAO experiments. PEEP markedly decreased t/sub 1/2/ to 13 +/- 3 min (P < 0.01), and PAO increased it to 37 +/- 6 min (P < 0.05). We conclude that clearance from the lungs by our method is uninfluenced by increased frequency, increases markedly with PEEP, and depends on pulmonary, not bronchial, blood flow.
- Research Organization:
- San Francisco General Hospital Medical Center, CA
- OSTI ID:
- 5905744
- Journal Information:
- J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States), Vol. 56:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Relationship of end-expiratory pressure, lung volume, and /sup 99m/Tc-DTPA clearance
Clearance of [sup 99m]Tc-labeled albumin from lungs in anesthetized guinea pigs
Related Subjects
54 ENVIRONMENTAL SCIENCES
AEROSOLS
DEPOSITION
LUNG CLEARANCE
PARTICULATES
ACETATES
BLOOD FLOW
DOGS
ISOMERIC NUCLEI
LABELLED COMPOUNDS
LUNGS
PARTICLE SIZE
TECHNETIUM 99
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID SALTS
CLEARANCE
COLLOIDS
DISPERSIONS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PARTICLES
RADIOISOTOPES
RESPIRATORY SYSTEM
SIZE
SOLS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)