Oscillatory mechanics of the respiratory system in ozone-exposed rats

Journal Article · Sun Jan 01 00:00:00 EST 1984 · J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States)

OSTI ID:5904286

Kotlikoff, M I; Jackson, A C; Watson, J W

The respiratory system impedance of tracheostomized cardiorespiratory disease-free Sprague-Dawley rats was measured from 20 to 90 Hz at constant flow amplitudes in 10 rats exposed to 0.64 ppm (UV) ozone for 7 days, and eight rats exposed to the same level of ozone for 20 days. This data was compared with respiratory system impedence spectra of 24 normal rats obtained in the same manner. When compared with control, the real part (effective resistance) was significantly different at several frequencies in the 7-day group (P < 0.05), and group means were higher at all frequencies. The 20-day group showed no significant differences in effective resistance. The imaginary part (effective reactance) was significantly lower at higher frequencies (f > 36) in both exposure groups (P < 0.05). When the impedance curves for each individual were fit to a lumped six-parameter model, and the parameters were compared, only the peripheral resistance parameter of the 7-day group was significantly different from control (P < 0.05). We conclude that ozone exposure at this level causes changes in respiratory system impedance, that these changes consist primarily of decreased reactances at higher frequencies, and that at 7 days these changes can be modeled by an increase in peripheral resistance.

• Research Organization: Univ. of California, Davis
• OSTI ID: 5904286
• Journal Information: J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States), Vol. 56:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OZONE
BIOLOGICAL EFFECTS
RATS
SENSITIVITY
RESPIRATORY SYSTEM
DYNAMIC FUNCTION STUDIES
ACUTE EXPOSURE
GHZ RANGE 01-100
IMPEDANCE
LUNGS
MATHEMATICAL MODELS
ANIMALS
BODY
FREQUENCY RANGE
GHZ RANGE
MAMMALS
ORGANS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism &amp; Toxicology- Vertebrates- (-1987)