In vivo and in vitro absorption and binding to powdered stratum corneum as methods to evaluate skin absorption of environmental chemical contaminants from ground and surface water

Journal Article · Thu Jan 01 00:00:00 EST 1987 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709531025· OSTI ID:5897193

Wester, R C; Mobayen, M; Maibach, H I

The objectives of this study were to compare methods to determine the binding and absorption of water contaminants to skin, to examine linearity of response, and to determine whether skin was an environmental route for water contaminants to enter the body. The three chemical examined were (/sup 14/C)-p-nitroaniline (10.1 mCi/mM), (/sup 14/C)benzene (56 mCi/mM, and /sup 14/C-labeled 54% PCB (32 mCi/mM). The chemical were added to distilled water and the concentration in water was determined by liquid scintillation counting.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5897193
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 21:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANILINE
SKIN ABSORPTION
BENZENE
CHLORINATED AROMATIC HYDROCARBONS
NITRO COMPOUNDS
BIOCHEMICAL REACTION KINETICS
CARBON 14 COMPOUNDS
ENVIRONMENTAL EXPOSURE PATHWAY
GROUND WATER
HEALTH HAZARDS
IN VITRO
IN VIVO
MAN
SCINTILLATION COUNTING
SURFACE WATERS
TRACER TECHNIQUES
WATER POLLUTION
ABSORPTION
AMINES
ANIMALS
AROMATICS
COUNTING TECHNIQUES
HALOGENATED AROMATIC HYDROCARBONS
HAZARDS
HYDROCARBONS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
POLLUTION
PRIMATES
REACTION KINETICS
UPTAKE
VERTEBRATES
WATER
560300* - Chemicals Metabolism & Toxicology