Radiation damage and repair in cells and cell components. Progress report, 1980-1981
One aim has been to see whether, in E.coli, the various phenomena which were ascribed to the induction of the recA gene produce (p-recA) are really manifestations of one process. It was concluded that this is true for septum inhibition, Weigle-reactivation, induced inhibition of post radiation DNA degradation, and with the additional concept of a premutational lesion, for uv mutagenesis. lambda prophage induction may perhaps be brought into line with p-recA induction with the consideration of the additional secondary aspects of (a) activation of p-recA to make it enzymatically active and (b) the need to have the concentration of activated p-recA high enough to keep up with the rate of production of lambda-repressors. Revertants seem to be in more than one class and two of these can not easily be explained by the idea that p-recA contains an error-prone repair enzyme that makes errors at mutagenic lesions.
- Research Organization:
- Duke Univ., Durham, NC (USA). Dept. of Zoology
- DOE Contract Number:
- AS05-76EV03631
- OSTI ID:
- 5894170
- Report Number(s):
- DOE/EV/03631-T1; ON: DE82000954; TRN: 82-001034
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BACTERIOPHAGES
RADIOINDUCTION
BIOLOGICAL REPAIR
GENETIC CONTROL
DNA
HOST-CELL REACTIVATION
PHOTOREACTIVATION
RADIOSENSITIVITY
ESCHERICHIA COLI
BIOLOGICAL RADIATION EFFECTS
GENETIC RADIATION EFFECTS
MUTATIONS
REVERTANTS
ULTRAVIOLET RADIATION
X RADIATION
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
CONTROL
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
IONIZING RADIATIONS
MICROORGANISMS
MUTANTS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
PEST CONTROL
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
VIRUSES
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