Dose dependency of time of onset of radiation-induced growth hormone deficiency

Journal Article · Fri Feb 01 00:00:00 EST 1991 · Journal of Pediatrics; (USA)

DOI:https://doi.org/10.1016/S0022-3476(05)80487-1· OSTI ID:5891458

Clayton, P E; Shalet, S M ^[1]

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1. Christie Hospital and Holt Radium Institute, Manchester (England)

Growth hormone (GH) secretion during insulin-induced hypoglycemia was assessed on 133 occasions in 82 survivors of childhood malignant disease. All had received cranial irradiation with a dose range to the hypothalamic-pituitary axis of 27 to 47.5 Gy (estimated by a schedule of 16 fractions over 3 weeks) and had been tested on one or more occasions between 0.2 and 18.9 years after treatment. Results of one third of the GH tests were defined as normal (GH peak response, greater than 15 mU/L) within the first 5 years, in comparison with 16% after 5 years. Stepwise multiple linear regression analysis showed that dose (p = 0.007) and time from irradiation (p = 0.03), but not age at therapy, had a significant influence on peak GH responses. The late incidence of GH deficiency was similar over the whole dose range (4 of 26 GH test results normal for less than 30 Gy and 4 of 25 normal for greater than or equal to 30 Gy after 5 years), but the speed of onset over the first years was dependent on dose. We conclude that the requirement for GH replacement therapy and the timing of its introduction will be influenced by the dose of irradiation received by the hypothalamic-pituitary axis.

• OSTI ID: 5891458
• Journal Information: Journal of Pediatrics; (USA), Vol. 118:2; ISSN 0022-3476
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RADIOTHERAPY
SIDE EFFECTS
STH
SECRETION
BRAIN
CHILDREN
DELAYED RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
HYPOTHALAMUS
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RADIATION DOSES
REGRESSION ANALYSIS
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DOSES
ENDOCRINE GLANDS
GLANDS
HORMONES
MATHEMATICS
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOLOGY
STATISTICS
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560151* - Radiation Effects on Animals- Man