Bronchoscopic phototherapy at comparable dose rates: Early results

Journal Article · Mon May 01 00:00:00 EDT 1989 · Ann. Thorac. Surg.; (United States)

DOI:https://doi.org/10.1016/0003-4975(89)90120-3· OSTI ID:5878783

Pass, H I; Delaney, T; Smith, P D; Bonner, R; Russo, A

Photodynamic therapy is a recently introduced treatment for surface malignancies. Since January 1987, 10 patients with endobronchial neoplasms have had bronchoscopic photodynamic therapy at similar dose rates (400 mW/cm) for total atelectasis (2), carinal narrowing with respiratory insufficiency (2), or partial obstruction without collapse (4). Two patients underwent photodynamic therapy as a preliminary to immunotherapy. Histologies included endobronchial metastases (colon, ovary, melanoma, and sarcoma, 1 each; and renal cell, 3) and primary lung cancer (3). The 2 patients with total atelectasis had complete reexpansion after photodynamic therapy, which permitted eventual sleeve lobectomy in 1. Carinal narrowing was ameliorated in the 2 patients seen with inspiratory stridor, thereby permitting hospital discharge. Endoscopically resected fragments after photodynamic therapy exhibited avascular necrosis. These data support further controlled studies of photodynamic therapy by thoracic surgical oncologists to define its limitations as well as to improve and expand its efficacy as a palliative or surgical adjuvant.

• Research Organization: National Cancer Institute, Bethesda, MD (USA)
• OSTI ID: 5878783
• Journal Information: Ann. Thorac. Surg.; (United States), Vol. 47:5, Issue 5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
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BRONCHI
NEOPLASMS
LASER RADIATION
BIOLOGICAL EFFECTS
THERAPY
CHEMOTHERAPY
DOSE-RESPONSE RELATIONSHIPS
HEMATOPORPHYRINS
LASERS
METASTASES
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CARBOXYLIC ACIDS
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HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
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ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
RADIATIONS
RESPIRATORY SYSTEM
550600* - Medicine
560400 - Other Environmental Pollutant Effects