Radioprotection by superoxide dismutase of macrophage progenitor cells from mouse bone marrow
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
X-ray survival of cultured macrophage progenitor cells from mouse bone marrow was represented by a two component curve, both in the absence and presence of superoxide dismutase. Protection by the enzyme was limited to the radiosensitive fraction, for which a dose modifying factor of 2.8 +/- 0.7 was obtained. Catalase did not protect. Survival of the radiosensitive fraction, with and without exogenous superoxide dismutase, was temperature-dependent, whereas that of the radioresistant fraction was not. In the former case, the energy required for the enzyme-treated cells was approx. 13kJ/mol. 15 references, 2 figures, 1 table.
- Research Organization:
- Atomic Energy of Canada Ltd. Res. Co., Pinawa, Manitoba
- OSTI ID:
- 5878142
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Vol. 119:3, Issue 3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MACROPHAGES
SURVIVAL TIME
SUPEROXIDE DISMUTASE
RADIOSENSITIVITY EFFECTS
BONE MARROW
EXPERIMENTAL DATA
MICE
TEMPERATURE DEPENDENCE
X RADIATION
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CONNECTIVE TISSUE CELLS
DATA
ELECTROMAGNETIC RADIATION
ENZYMES
HEMATOPOIETIC SYSTEM
INFORMATION
IONIZING RADIATIONS
MAMMALS
NUMERICAL DATA
ORGANS
OXIDOREDUCTASES
PHAGOCYTES
RADIATIONS
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)
MACROPHAGES
SURVIVAL TIME
SUPEROXIDE DISMUTASE
RADIOSENSITIVITY EFFECTS
BONE MARROW
EXPERIMENTAL DATA
MICE
TEMPERATURE DEPENDENCE
X RADIATION
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CONNECTIVE TISSUE CELLS
DATA
ELECTROMAGNETIC RADIATION
ENZYMES
HEMATOPOIETIC SYSTEM
INFORMATION
IONIZING RADIATIONS
MAMMALS
NUMERICAL DATA
ORGANS
OXIDOREDUCTASES
PHAGOCYTES
RADIATIONS
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)